Prediction of preeclampsia utilizing the first trimester screening examination.
Prediction of preeclampsia utilizing the first trimester screening examination.
- 2014
Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
CONCLUSION: First trimester prediction rules using parameters currently available at first trimester screening identify a significant proportion of women with subsequent preeclampsia.Copyright © 2014 Elsevier Inc. All rights reserved. OBJECTIVE: To derive a prediction rule for preeclampsia and early onset preeclampsia requiring delivery <34 weeks using first trimester maternal, ultrasound, and serum markers. RESULTS: In 2441 women, 108 (4.4%) women developed preeclampsia, and 18 (0.7%) early preeclampsia. Nulliparity, prior hypertension, diabetes, prior preeclampsia, mean arterial pressure, and the log pregnancy-associate pregnancy protein-A multiples of the median were primary risk factors. Prediction rules for preeclampsia/early preeclampsia had an area under the curve of 0.82/0.83 respectively. Preeclampsia was predicted with 49% sensitivity and early preeclampsia with 55% sensitivity for a 10% false positive rate. STUDY DESIGN: Prospective cohort study of women enrolled at first trimester screening. Maternal history, demographics, anthropometry, ultrasound parameters, and serum analytes were compared between women with preeclampsia and normal outcome. The prediction rule was derived by Lasso logistic regression analysis.
English
0002-9378
*Hypertension/ep [Epidemiology]
*Pre-Eclampsia/di [Diagnosis]
*Pregnancy Complications, Cardiovascular/ep [Epidemiology]
*Pregnancy in Diabetics/ep [Epidemiology]
*Uterine Artery/us [Ultrasonography]
Adolescent
Adult
Area Under Curve
Biomarkers/bl [Blood]
Blood Pressure
Cohort Studies
Female
Humans
Logistic Models
Parity
Pre-Eclampsia/bl [Blood]
Pre-Eclampsia/us [Ultrasonography]
Pregnancy
Pregnancy Trimester, First/bl [Blood]
Pregnancy-Associated Plasma Protein-A/me [Metabolism]
Prenatal Diagnosis
Prognosis
Prospective Studies
Risk Assessment
Ultrasonography, Prenatal
Young Adult
MedStar Franklin Square Medical Center
MedStar Harbor Hospital
Obstetrics and Gynecology
Journal Article
Research Support, Non-U.S. Gov't
Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
CONCLUSION: First trimester prediction rules using parameters currently available at first trimester screening identify a significant proportion of women with subsequent preeclampsia.Copyright © 2014 Elsevier Inc. All rights reserved. OBJECTIVE: To derive a prediction rule for preeclampsia and early onset preeclampsia requiring delivery <34 weeks using first trimester maternal, ultrasound, and serum markers. RESULTS: In 2441 women, 108 (4.4%) women developed preeclampsia, and 18 (0.7%) early preeclampsia. Nulliparity, prior hypertension, diabetes, prior preeclampsia, mean arterial pressure, and the log pregnancy-associate pregnancy protein-A multiples of the median were primary risk factors. Prediction rules for preeclampsia/early preeclampsia had an area under the curve of 0.82/0.83 respectively. Preeclampsia was predicted with 49% sensitivity and early preeclampsia with 55% sensitivity for a 10% false positive rate. STUDY DESIGN: Prospective cohort study of women enrolled at first trimester screening. Maternal history, demographics, anthropometry, ultrasound parameters, and serum analytes were compared between women with preeclampsia and normal outcome. The prediction rule was derived by Lasso logistic regression analysis.
English
0002-9378
*Hypertension/ep [Epidemiology]
*Pre-Eclampsia/di [Diagnosis]
*Pregnancy Complications, Cardiovascular/ep [Epidemiology]
*Pregnancy in Diabetics/ep [Epidemiology]
*Uterine Artery/us [Ultrasonography]
Adolescent
Adult
Area Under Curve
Biomarkers/bl [Blood]
Blood Pressure
Cohort Studies
Female
Humans
Logistic Models
Parity
Pre-Eclampsia/bl [Blood]
Pre-Eclampsia/us [Ultrasonography]
Pregnancy
Pregnancy Trimester, First/bl [Blood]
Pregnancy-Associated Plasma Protein-A/me [Metabolism]
Prenatal Diagnosis
Prognosis
Prospective Studies
Risk Assessment
Ultrasonography, Prenatal
Young Adult
MedStar Franklin Square Medical Center
MedStar Harbor Hospital
Obstetrics and Gynecology
Journal Article
Research Support, Non-U.S. Gov't