Approach to the surgical management of resectable gastric cancer. [Review]
Approach to the surgical management of resectable gastric cancer. [Review]
- 2016
The rates of gastric cancer, which is the third leading cause of cancer-related deaths worldwide, vary depending on geographic location. Margin-negative gastrectomy and adequate lymphadenectomy (removal of >15 lymph nodes) are the cornerstones of multimodal treatment for operable gastric cancer. Diagnostic laparoscopy should be included in the armamentarium for newly diagnosed gastric cancer in order to overcome the limitations of cross-sectional imaging in identifying sub-radiographic hepatic or peritoneal metastases. The benefit of surgical therapy is enhanced by at least 13% when it is integrated with multimodal therapy: either surgery followed by adjuvant chemoradiotherapy or surgery with perioperative systemic therapy. This multidisciplinary approach to treatment will continue to be an evolving paradigm, especially with the emergence of systemic and targeted therapies.
English
1543-0790
*Stomach Neoplasms/di [Diagnosis]
*Stomach Neoplasms/su [Surgery]
Biomarkers, Tumor
Clinical Decision-Making
Clinical Trials as Topic
Combined Modality Therapy
Disease Management
Gastrectomy/mt [Methods]
Humans
Incidence
Lymph Node Excision
Neoplasm Staging/mt [Methods]
Palliative Care
Preoperative Care
Stomach Neoplasms/ep [Epidemiology]
Stomach Neoplasms/mo [Mortality]
Treatment Outcome
MedStar Health Research Institute
Journal Article
Review
The rates of gastric cancer, which is the third leading cause of cancer-related deaths worldwide, vary depending on geographic location. Margin-negative gastrectomy and adequate lymphadenectomy (removal of >15 lymph nodes) are the cornerstones of multimodal treatment for operable gastric cancer. Diagnostic laparoscopy should be included in the armamentarium for newly diagnosed gastric cancer in order to overcome the limitations of cross-sectional imaging in identifying sub-radiographic hepatic or peritoneal metastases. The benefit of surgical therapy is enhanced by at least 13% when it is integrated with multimodal therapy: either surgery followed by adjuvant chemoradiotherapy or surgery with perioperative systemic therapy. This multidisciplinary approach to treatment will continue to be an evolving paradigm, especially with the emergence of systemic and targeted therapies.
English
1543-0790
*Stomach Neoplasms/di [Diagnosis]
*Stomach Neoplasms/su [Surgery]
Biomarkers, Tumor
Clinical Decision-Making
Clinical Trials as Topic
Combined Modality Therapy
Disease Management
Gastrectomy/mt [Methods]
Humans
Incidence
Lymph Node Excision
Neoplasm Staging/mt [Methods]
Palliative Care
Preoperative Care
Stomach Neoplasms/ep [Epidemiology]
Stomach Neoplasms/mo [Mortality]
Treatment Outcome
MedStar Health Research Institute
Journal Article
Review