Admission Neutrophil to Lymphocyte Ratio for Predicting Outcome in Subarachnoid Hemorrhage.
Admission Neutrophil to Lymphocyte Ratio for Predicting Outcome in Subarachnoid Hemorrhage.
- 2021
CONCLUSIONS: Higher admission NLR is an independent predictor for poor functional outcome at discharge in aSAH patients. The evaluation of anti-inflammatory targets in the future may allow for improved functional outcome after aSAH. Copyright (c) 2021 Elsevier Inc. All rights reserved. MATERIAL AND METHODS: Consecutive patients with aSAH were treated at two tertiary stroke centers during a five-year period. Functional outcome was defined as discharge modified Rankin score dichotomized at scores 0-2 (good) vs. 3-6 (poor). PURPOSE: We sought to evaluate the relationship between admission neutrophil-to-lymphocyte ratio (NLR) and functional outcome in aneurysmal subarachnoid hemorrhage (aSAH) patients. RESULTS: 474 aSAH patients were evaluated with a mean NLR 8.6 (SD 8.3). In multivariable logistic regression analysis, poor functional outcome was independently associated with higher NLR, older age, poorer clinical status on admission, prehospital statin use, and vasospasm. Increasing NLR analyzed as a continuous variable was independently associated with higher odds of poor functional outcome (OR 1.03, 95%CI 1.00-1.07, p=0.05) after adjustment for potential confounders. When dichotomized using ROC curve analysis, a threshold NLR value of greater than 6.48 was independently associated with higher odds of poor functional outcome (OR 1.71, 95%CI 1.07-2.74, p=0.03) after adjustment for potential confounders.
English
1052-3057
10.1016/j.jstrokecerebrovasdis.2021.105936 [doi] S1052-3057(21)00339-6 [pii]
*Lymphocytes/im [Immunology]
*Neutrophils/im [Immunology]
*Patient Admission
*Subarachnoid Hemorrhage/di [Diagnosis]
Adult
Aged
Biomarkers/bl [Blood]
Disability Evaluation
Female
Humans
Lymphocyte Count
Male
Middle Aged
Patient Discharge
Predictive Value of Tests
Prognosis
Retrospective Studies
Subarachnoid Hemorrhage/im [Immunology]
Subarachnoid Hemorrhage/pp [Physiopathology]
Subarachnoid Hemorrhage/th [Therapy]
United States
MedStar Washington Hospital Center
Neurosurgery
Neurosurgery Residency
Nursing
Radiology
Surgery/Surgical Critical Care
Journal Article
CONCLUSIONS: Higher admission NLR is an independent predictor for poor functional outcome at discharge in aSAH patients. The evaluation of anti-inflammatory targets in the future may allow for improved functional outcome after aSAH. Copyright (c) 2021 Elsevier Inc. All rights reserved. MATERIAL AND METHODS: Consecutive patients with aSAH were treated at two tertiary stroke centers during a five-year period. Functional outcome was defined as discharge modified Rankin score dichotomized at scores 0-2 (good) vs. 3-6 (poor). PURPOSE: We sought to evaluate the relationship between admission neutrophil-to-lymphocyte ratio (NLR) and functional outcome in aneurysmal subarachnoid hemorrhage (aSAH) patients. RESULTS: 474 aSAH patients were evaluated with a mean NLR 8.6 (SD 8.3). In multivariable logistic regression analysis, poor functional outcome was independently associated with higher NLR, older age, poorer clinical status on admission, prehospital statin use, and vasospasm. Increasing NLR analyzed as a continuous variable was independently associated with higher odds of poor functional outcome (OR 1.03, 95%CI 1.00-1.07, p=0.05) after adjustment for potential confounders. When dichotomized using ROC curve analysis, a threshold NLR value of greater than 6.48 was independently associated with higher odds of poor functional outcome (OR 1.71, 95%CI 1.07-2.74, p=0.03) after adjustment for potential confounders.
English
1052-3057
10.1016/j.jstrokecerebrovasdis.2021.105936 [doi] S1052-3057(21)00339-6 [pii]
*Lymphocytes/im [Immunology]
*Neutrophils/im [Immunology]
*Patient Admission
*Subarachnoid Hemorrhage/di [Diagnosis]
Adult
Aged
Biomarkers/bl [Blood]
Disability Evaluation
Female
Humans
Lymphocyte Count
Male
Middle Aged
Patient Discharge
Predictive Value of Tests
Prognosis
Retrospective Studies
Subarachnoid Hemorrhage/im [Immunology]
Subarachnoid Hemorrhage/pp [Physiopathology]
Subarachnoid Hemorrhage/th [Therapy]
United States
MedStar Washington Hospital Center
Neurosurgery
Neurosurgery Residency
Nursing
Radiology
Surgery/Surgical Critical Care
Journal Article