MARC details
| 000 -LEADER |
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| fixed length control field |
05150nam a22005057a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
130917s20122012 xxu||||| |||| 00| 0 eng dOvid Technologies |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0028-4793 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
23034020 |
| 245 ## - TITLE STATEMENT |
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| Title |
C-reactive protein, fibrinogen, and cardiovascular disease prediction. |
| 251 ## - Source |
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| Source |
New England Journal of Medicine. 367(14):1310-20, 2012 Oct 4. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
N Engl J Med. 367(14):1310-20, 2012 Oct 4. |
| 253 ## - Journal Name |
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| Journal name |
The New England journal of medicine |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2013-09-17 |
| 501 ## - WITH NOTE |
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| Local holdings |
Available online from MWHC library: 1993 - present, Available in print through MWHC library: 1980 - present |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
BACKGROUND: There is debate about the value of assessing levels of C-reactive protein (CRP) and other biomarkers of inflammation for the prediction of first cardiovascular events. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSIONS: In a study of people without known cardiovascular disease, we estimated that under current treatment guidelines, assessment of the CRP or fibrinogen level in people at intermediate risk for a cardiovascular event could help prevent one additional event over a period of 10 years for every 400 to 500 people screened. (Funded by the British Heart Foundation and others.). |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
METHODS: We analyzed data from 52 prospective studies that included 246,669 participants without a history of cardiovascular disease to investigate the value of adding CRP or fibrinogen levels to conventional risk factors for the prediction of cardiovascular risk. We calculated measures of discrimination and reclassification during follow-up and modeled the clinical implications of initiation of statin therapy after the assessment of CRP or fibrinogen. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
RESULTS: The addition of information on high-density lipoprotein cholesterol to a prognostic model for cardiovascular disease that included age, sex, smoking status, blood pressure, history of diabetes, and total cholesterol level increased the C-index, a measure of risk discrimination, by 0.0050. The further addition to this model of information on CRP or fibrinogen increased the C-index by 0.0039 and 0.0027, respectively (P<0.001), and yielded a net reclassification improvement of 1.52% and 0.83%, respectively, for the predicted 10-year risk categories of "low" (<10%), "intermediate" (10% to <20%), and "high" (>=20%) (P<0.02 for both comparisons). We estimated that among 100,000 adults 40 years of age or older, 15,025 persons would initially be classified as being at intermediate risk for a cardiovascular event if conventional risk factors alone were used to calculate risk. Assuming that statin therapy would be initiated in accordance with Adult Treatment Panel III guidelines (i.e., for persons with a predicted risk of >=20% and for those with certain other risk factors, such as diabetes, irrespective of their 10-year predicted risk), additional targeted assessment of CRP or fibrinogen levels in the 13,199 remaining participants at intermediate risk could help prevent approximately 30 additional cardiovascular events over the course of 10 years. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*C-Reactive Protein/me [Metabolism] |
| 9 (RLIN) |
400 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Cardiovascular Diseases/pc [Prevention & Control] |
| 9 (RLIN) |
402 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Fibrinogen/me [Metabolism] |
| 9 (RLIN) |
403 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Adult |
| 9 (RLIN) |
13 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Biological Markers/bl [Blood] |
| 9 (RLIN) |
399 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cardiovascular Diseases/bl [Blood] |
| 9 (RLIN) |
401 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Cohort Studies |
| 9 (RLIN) |
187 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Female |
| 9 (RLIN) |
7 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Humans |
| 9 (RLIN) |
11 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Lipids/bl [Blood] |
| 9 (RLIN) |
404 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Male |
| 9 (RLIN) |
14 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Mass Screening |
| 9 (RLIN) |
405 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Middle Aged |
| 9 (RLIN) |
15 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Practice Guidelines as Topic |
| 9 (RLIN) |
406 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Prognosis |
| 9 (RLIN) |
280 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Proportional Hazards Models |
| 9 (RLIN) |
265 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Risk Factors |
| 9 (RLIN) |
311 |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Research Support, Non-U.S. Gov't |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Howard, Barbara V |
| 9 (RLIN) |
398 |
| 790 ## - Authors |
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| All authors |
Amouyel P, Assmann G, Bakker SJ, Barr EL, Barrett-Connor E, Benjamin EJ, Bjorkelund C, Brenner H, Brunner E, Butterworth AS, Caslake M, Clarke R, Cooper JA, Cremer P, Cushman M, D'Agostino RB Sr, Dagenais GR, Danesh J, Dankner R, Davey-Smith G, Deeg D, Dekker JM, Di Angelantonio E, Emerging Risk Factors Collaboration, Engstrom G, Folsom AR, Ford I, Fowkes FG, Gallacher J, Gao P, Gaziano JM, Giampaoli S, Gillum RF, Gudnason V, Hofman A, Howard BV, Ingelsson E, Iso H, Jorgensen T, Kaptoge S, Kauhanen J, Khaw KT, Kiechl S, Kitamura A, Kiyohara Y, Koenig W, Kromhout D, Kuller LH, Lawlor DA, Lowe GD, Meade TW, Nissinen A, Nordestgaard BG, Onat A, Packard CJ, Panagiotakos DB, Pennells L, Pepys MB, Psaty BM, Ridker PM, Rodriguez B, Rosengren A, Salomaa V, Salonen JT, Sarwar N, Sattar N, Shaffer JA, Shea S, Stehouwer CD, Strandberg TE, Thompson A, Thompson SG, Tipping RW, Tosetto A, Walker M, Wareham NJ, Wassertheil-Smoller S, Wennberg P, Westendorp RG, Whincup PH, White IR, Wilhelmsen L, Wood AM, Woodward M |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="http://dx.doi.org/10.1056/NEJMoa1107477">http://dx.doi.org/10.1056/NEJMoa1107477</a> |
| Public note |
http://dx.doi.org/10.1056/NEJMoa1107477 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Journal article |
| Source of classification or shelving scheme |
Other/Generic Classification Scheme |
