Changes in Left Ventricular Global Longitudinal Strain in Patients With Heart Failure and Secondary Mitral Regurgitation: The COAPT Trial. (Record no. 13557)
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fixed length control field | 04016nam a22005177a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
fixed length control field | 232233s20232023 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
International Standard Serial Number | 2047-9980 |
024 ## - OTHER STANDARD IDENTIFIER | |
Standard number or code | 10.1161/JAHA.122.029956 [doi] |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
PMID | 37646214 |
245 ## - TITLE STATEMENT | |
Title | Changes in Left Ventricular Global Longitudinal Strain in Patients With Heart Failure and Secondary Mitral Regurgitation: The COAPT Trial. |
251 ## - Source | |
Source | Journal of the American Heart Association. 12(17):e029956, 2023 09 05. |
252 ## - Abbreviated Source | |
Abbreviated source | J Am Heart Assoc. 12(17):e029956, 2023 09 05. |
253 ## - Journal Name | |
Journal name | Journal of the American Heart Association |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Year | 2023 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Manufacturer | FY2024 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Publication date | 2023 09 05 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
Publication status | ppublish |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
Medline status | MEDLINE |
266 ## - Date added to catalog | |
Date added to catalog | 2023-11-22 |
520 ## - SUMMARY, ETC. | |
Abstract | Background Left ventricular (LV) global longitudinal strain (GLS) provides incremental prognostic information over LV ejection fraction in patients with heart failure (HF) and secondary mitral regurgitation. We examined the prognostic impact of LV GLS improvement in this population. Methods and Results The COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation) trial randomized symptomatic patients with HF with severe (3+/4+) mitral regurgitation to transcatheter edge-to-edge repair with the MitraClip device plus maximally tolerated guideline-directed medical therapy (GDMT) versus GDMT alone. LV GLS was measured at baseline and 6-month follow-up. The relationship between the improvement in LV GLS from baseline to 6 months and the composite of all-cause death or HF hospitalization between 6- and 24-month follow-up were assessed. Among 383 patients, 174 (45.4%) had improved LV GLS at 6-month follow-up (83/195 [42.6%] with transcatheter edge-to-edge repair+GDMT and 91/188 [48.4%] with GDMT alone; P=0.25). Improvement in LV GLS was strongly associated with reduced death or HF hospitalization between 6 and 24 months (P<0.009), with similar risk reduction in both treatment arms (Pinteraction=0.40). By multivariable analysis, LV GLS improvement at 6 months was independently associated with a lower risk of death or HF hospitalization (hazard ratio [HR], 0.55 [95% CI, 0.36-0.83]; P=0.009), death (HR, 0.48 [95% CI, 0.29-0.81]; P=0.006), and HF hospitalization (HR, 0.50 [95% CI, 0.31-0.81]; P=0.005) between 6 and 24 months. Conclusions Among patients with HF and severe mitral regurgitation in the COAPT trial, improvement in LV GLS at 6-month follow-up was associated with improved outcomes after both transcatheter edge-to-edge repair and GDMT alone between 6 and 24 months. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT01626079. |
546 ## - LANGUAGE NOTE | |
Language note | English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | *Heart Failure |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | *Mitral Valve Insufficiency |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Global Longitudinal Strain |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Heart Failure/th [Therapy] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Hospitalization |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Humans |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Mitral Valve Insufficiency/dg [Diagnostic Imaging] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Mitral Valve Insufficiency/et [Etiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Mitral Valve Insufficiency/su [Surgery] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | Outcome Assessment, Health Care |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Indexing | Curated |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
Institution | MedStar Health Research Institute |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
Institution | MedStar Heart & Vascular Institute |
657 ## - INDEX TERM--FUNCTION | |
Medline publication type | Journal Article |
657 ## - INDEX TERM--FUNCTION | |
Medline publication type | Randomized Controlled Trial |
657 ## - INDEX TERM--FUNCTION | |
Medline publication type | Research Support, Non-U.S. Gov't |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Local Authors | Asch, Federico M |
Institution Code | MHRI |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Local Authors | Medvedofsky, Diego |
Institution Code | MHVI |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Local Authors | Weissman, Neil J |
Institution Code | MHRI |
790 ## - Authors | |
All authors | Pio SM, Medvedofsky D, Stassen J, Delgado V, Namazi F, Weissman NJ, Grayburn P, Kar S, Lim DS, Zhou Z, Alu MC, Redfors B, Kapadia S, Lindenfeld J, Abraham WT, Mack MJ, Asch FM, Stone GW, Bax JJ |
856 ## - ELECTRONIC LOCATION AND ACCESS | |
DOI | <a href="https://dx.doi.org/10.1161/JAHA.122.029956">https://dx.doi.org/10.1161/JAHA.122.029956</a> |
Public note | https://dx.doi.org/10.1161/JAHA.122.029956 |
858 ## - ORCID | |
ORCID text | Asch, Federico M |
Orcid | <a href="https://orcid.org/0000-0002-1744-5271">https://orcid.org/0000-0002-1744-5271</a> |
Name | https://orcid.org/0000-0002-1744-5271 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Koha item type | Journal Article |
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No items available.