MARC details
| 000 -LEADER |
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| fixed length control field |
03989nam a22005777a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
180316s20182018 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1046-7408 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1111/aji.12846 [doi] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
29533494 |
| 245 ## - TITLE STATEMENT |
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| Title |
Immune biomarkers and anti-HIV activity in the reproductive tract of sexually active and sexually inactive adolescent girls. |
| 251 ## - Source |
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| Source |
American Journal of Reproductive Immunology. 79(6):e12846, 2018 06. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Am J Reprod Immunol. 79(6):e12846, 2018 06. |
| 253 ## - Journal Name |
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| Journal name |
American journal of reproductive immunology (New York, N.Y. : 1989) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2018 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2018 |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2018-04-19 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSION: Higher pro-inflammatory biomarker TNF-alpha, as well as a distinct inflammation-associated immune clustering in sexually inactive girls, can potentially increase risk for infections including HIV upon sexual debut. Future studies with larger sample sizes are needed to characterize the immune parameters associated with sexual activity. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Copyright (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
METHODS: Cervico-vaginal lavage (CVL) was collected from sexually active (10) and inactive (8) girls aged 11-19 years and analyzed by ELISA for inflammation-associated biomarkers IL-6, IL-8, TNF-alpha, MIP-3alpha, IL-1alpha, IL-1beta, matrix metalloproteinases (MMP) 1, 2, 7, 8, and 9, as well as anti-HIV mediators, Elafin, SLPI, human beta-defensin 2, and tissue inhibitor of matrix metalloproteinases (TIMP) 1 and 2. Cervical ectopy was analyzed using Volocity. Anti-HIV activity was determined by TZM-bl assay. Statistical analyses were performed using GraphPad Prism and R. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
PROBLEM: Adolescent girls are disproportionately affected by the HIV/AIDS pandemic, accounting for 22% of all new HIV infections globally. Yet little is known regarding the immune microenvironment of the adolescent female reproductive tract, especially regarding differences among sexually active and inactive girls, a critical parameter to evaluate HIV susceptibility associated with young age and sexual debut. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
RESULTS: Sexually inactive girls had significantly higher levels of TNF-alpha (P = .029) in CVL compared to sexually active girls. In contrast, sexually active girls showed a trend toward higher levels of IL-1alpha (P = .051) compared to the sexually inactive girls. Heat-map correlations between cervical ectopy and immune biomarkers were also distinct between the 2 populations with significant positive associations between % ectopy and inflammation-associated biomarkers IL-6, IL-1beta, IL-8, MIP-3alpha, MMP-8, and MMP-9 observed in the sexually inactive but not sexually active group. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Biomarkers/me [Metabolism] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Genitalia, Female/im [Immunology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Genitalia, Female/me [Metabolism] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Genitalia, Female/vi [Virology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*HIV-1/im [Immunology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Reproduction/im [Immunology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Sexual Behavior/ph [Physiology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Adolescent |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Adult |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Cytokines/im [Immunology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Female |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
HIV Infections/im [Immunology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Humans |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Inflammation/im [Immunology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Inflammation/me [Metabolism] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Vaginal Douching/mt [Methods] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Young Adult |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Obstetrics and Gynecology/Pediatric and Adolescent |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Emmanuel, Vanessa |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Gomez-Lobo, Veronica |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Jarin, Jason |
| 790 ## - Authors |
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| All authors |
Biswas R, Daniels J, Emmanuel V, Ghosh M, Gomez-Lobo V, Jais M, Jarin J, Joy C, Juzumaite M |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1111/aji.12846">https://dx.doi.org/10.1111/aji.12846</a> |
| Public note |
https://dx.doi.org/10.1111/aji.12846 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
