MARC details
| 000 -LEADER |
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| fixed length control field |
02637nam a22004097a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
201229s20192019 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
2307-8960 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
30842952 |
| 245 ## - TITLE STATEMENT |
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| Title |
Immune checkpoint inhibitor-induced colitis: A comprehensive review. [Review] |
| 251 ## - Source |
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| Source |
World Journal of Clinical Cases. 7(4):405-418, 2019 Feb 26. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
World j. clin. cases. 7(4):405-418, 2019 Feb 26. |
| 253 ## - Journal Name |
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| Journal name |
World journal of clinical cases |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2019 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2019 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
ppublish |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2020-12-29 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that target down-regulators of the anti-cancer immune response: Cytotoxic T-lymphocyte antigen-4, programmed cell death protein-1, and its ligand programmed death-ligand 1. ICIs have revolutionized the treatment of a variety of malignancies. However, many immune-related adverse events have also been described which mainly occurs as the immune system becomes less suppressed, affecting various organs including the gastrointestinal tract and causing diarrhea and colitis. The incidence of immune-mediated colitis (IMC) ranges from 1%-25% depending on the type of ICI and if used in combination. Endoscopically and histologically there is a significant overlap between IMC and inflammatory bowel disease, however more neutrophilic inflammation without chronic inflammation is usually present in IMC. Corticosteroids are recommended for grade 2 or more severe colitis while holding the immunotherapy. About one third to two thirds of patients are steroid refractory and benefit from infliximab. Recently vedolizumab has been found to be efficacious in steroid and infliximab refractory cases. While in grade 4 colitis, the immunotherapy is permanently discontinued, the decision is controversial in grade 3 colitis. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Gastroenterology |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Gastroenterology/Hepatology |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Internal Medicine |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Medicine/Internal Medicine |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
MedStar MedStar Union Memorial Hospital |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Review |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Alsaadi, Dana |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Farshidpour, Maham |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Malhotra, Nidhi |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Mandaliya, Rohan |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Som, Aniruddh |
| 790 ## - Authors |
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| All authors |
Alsaadi D, Charabaty A, Farshidpour M, Malhotra N, Mandaliya R, Mattar MC, Som A |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.12998/wjcc.v7.i4.405">https://dx.doi.org/10.12998/wjcc.v7.i4.405</a> |
| Public note |
https://dx.doi.org/10.12998/wjcc.v7.i4.405 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
