Insecticide exposure and farm history in relation to risk of lymphomas and leukemias in the Women's Health Initiative observational study cohort.
Citation: Annals of Epidemiology. 25(11):803-10, 2015 Nov.PMID: 26365305Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | Observational Study | Research Support, N.I.H., Extramural | Research Support, N.I.H., IntramuralSubject headings: *Agriculture | *Insecticides/po [Poisoning] | *Leukemia/ci [Chemically Induced] | *Leukemia/ep [Epidemiology] | *Lymphoma/ci [Chemically Induced] | *Lymphoma/ep [Epidemiology] | Adult | Aged | Cohort Studies | Female | Humans | Middle Aged | Population Surveillance | Postmenopause/de [Drug Effects] | Proportional Hazards Models | Prospective Studies | Risk Factors | Surveys and Questionnaires | United States/ep [Epidemiology] | Women's HealthYear: 2015ISSN:- 1047-2797
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 26365305 | Available | 26365305 |
CONCLUSIONS: Insecticide exposures may contribute to risk of CLL/SLL and DLBCL. Future studies should examine relationships of LH subtypes with specific types of household insecticides.Copyright © 2015 Elsevier Inc. All rights reserved.
METHODS: In questionnaires, women self-reported history living or working on a farm, personally mixing or applying insecticides, insecticide application in the home or workplace by a commercial service, and treating pets with insecticides. Relationships with non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, plasma cell neoplasms, and myeloid leukemia were investigated using Cox proportional hazard models. Age and farming history were explored as effect modifiers.
PURPOSE: Relationships of farm history and insecticide exposure at home or work with lymphohematopoietic (LH) neoplasm risk were investigated in a large prospective cohort of US women.
RESULTS: The analysis included 76,493 women and 822 NHL cases. Women who ever lived or worked on a farm had 1.12 times the risk of NHL (95% confidence interval [CI] = 0.95-1.32) compared to those who did not. Women who reported that a commercial service ever applied insecticides in their immediate surroundings had 65% higher risk of CLL/SLL (95% CI = 1.15-2.38). Women aged less than 65 years who ever applied insecticides had 87% higher risk of DLBCL (95% CI = 1.13-3.09).
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