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Influence of education on cognitive performance and dopamine transporter binding in dementia with Lewy bodies.

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Citation: Clinical Neurology & Neurosurgery. 146:138-43, 2016 JulPMID: 27209028Institution: MedStar Washington Hospital CenterDepartment: NeurologyIN - Lamotte, Guillaume. Department of Neurology, University Hospital of Caen, Avenue Cote de Nacre, 14033 Caen, France; Department of Neurology, MedStar Georgetown University Hospital, Washington, DC, USA. Electronic address: [email protected] - Morello, Remy. Department of Statistics and Clinical Research, University Hospital of Caen, France.IN - Lebasnier, Adrien. Department of Nuclear Medicine, University Hospital of Caen, EA 4650, France.IN - Agostini, Denis. Department of Nuclear Medicine, University Hospital of Caen, EA 4650, France.IN - Bouvard, Gerard. Department of Nuclear Medicine, University Hospital of Caen, EA 4650, France.IN - De La Sayette, Vincent. Department of Neurology, University Hospital of Caen, Avenue Cote de Nacre, 14033 Caen, France; Unite INSERM U1077, Neuropsychologie et neuroanatomie fonctionnelle de la memoire humaine, Universite de Caen Basse, Normandie, France.IN - Defer, Gilles L. Department of Neurology, University Hospital of Caen, Avenue Cote de Nacre, 14033 Caen, France; Unite INSERM U919, Serine protease et physiopathologie de l'Unite Neurovasculaire, GIP Cyceron, Universite Caen Basse, Normandie, France.Form of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Cognitive Reserve/ph [Physiology] | *Corpus Striatum/me [Metabolism] | *Dopamine Plasma Membrane Transport Proteins/me [Metabolism] | *Lewy Body Disease/me [Metabolism] | *Lewy Body Disease/pp [Physiopathology] | Aged | Education | Female | Humans | Male | Tomography, Emission-Computed, Single-PhotonYear: 2016 ISSN:

0303-8467

Name of journal: Clinical neurology and neurosurgeryAbstract: CONCLUSION: Higher education may have a protective effect on visuoconstructive performance and verbal retrieval strategies and may influence dopaminergic nigrostriatal neurodegeneration in patients with DLB.Copyright © 2016 Elsevier B.V. All rights reserved.MATERIALS AND METHODS: We reviewed 56 consecutive patients with DLB who underwent a 123-I-Ioflupane SPECT from January 2009 to August 2013 at the University Hospital of Caen. We collected clinical and neuropsychological data from medical files and 123-I-Ioflupane SPECT data for all patients.OBJECTIVES: Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are the two most common forms of dementia. These two diseases share some clinical and pathological similarities, yet the loss of dopaminergic neurons confirmed by 123-I-Ioflupane Single Photon Emission Computed Tomography (SPECT) is a suggestive feature of DLB. Current evidence suggests that higher education has a protective effect on the risk of developing clinical AD. However, how education influences cognitive performance and the presynaptic dopamine transporter marker in DLB is unknown.RESULTS: There was no correlation between education and global cognitive performance in patients with DLB. However, there was a positive correlation between education and tests exploring visuoconstructive functions (Rey complex figure copy and recall) and verbal retrieval strategies (Grober and Buschke free recall test). There was also a positive correlation between education and dopamine transporter binding. Higher educated patients had higher binding in the striatum, putamen and caudate nucleus (p=0.001 for each regions of interest). Dopamine transporter binding in the striatum, putamen and caudate nucleus was lower in the subgroup of patients with REM sleep behavior disorder, but was not associated with other DLB symptoms.All authors: Agostini D, Bouvard G, De La Sayette V, Defer GL, Lamotte G, Lebasnier A, Morello RFiscal year: FY2017Digital Object Identifier:

https://dx.doi.org/10.1016/j.clineuro.2016.05.009

Date added to catalog: 2017-05-06

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Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	27209028	Available		27209028

CONCLUSION: Higher education may have a protective effect on visuoconstructive performance and verbal retrieval strategies and may influence dopaminergic nigrostriatal neurodegeneration in patients with DLB.

MATERIALS AND METHODS: We reviewed 56 consecutive patients with DLB who underwent a 123-I-Ioflupane SPECT from January 2009 to August 2013 at the University Hospital of Caen. We collected clinical and neuropsychological data from medical files and 123-I-Ioflupane SPECT data for all patients.

OBJECTIVES: Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are the two most common forms of dementia. These two diseases share some clinical and pathological similarities, yet the loss of dopaminergic neurons confirmed by 123-I-Ioflupane Single Photon Emission Computed Tomography (SPECT) is a suggestive feature of DLB. Current evidence suggests that higher education has a protective effect on the risk of developing clinical AD. However, how education influences cognitive performance and the presynaptic dopamine transporter marker in DLB is unknown.

RESULTS: There was no correlation between education and global cognitive performance in patients with DLB. However, there was a positive correlation between education and tests exploring visuoconstructive functions (Rey complex figure copy and recall) and verbal retrieval strategies (Grober and Buschke free recall test). There was also a positive correlation between education and dopamine transporter binding. Higher educated patients had higher binding in the striatum, putamen and caudate nucleus (p=0.001 for each regions of interest). Dopamine transporter binding in the striatum, putamen and caudate nucleus was lower in the subgroup of patients with REM sleep behavior disorder, but was not associated with other DLB symptoms.

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