Sedentary time and postmenopausal breast cancer incidence.
Citation: Cancer Causes & Control. 28(12):1405-1416, 2017 Dec.PMID: 28975422Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Breast Neoplasms/ep [Epidemiology] | *Postmenopause | *Sedentary Lifestyle | Aged | Breast Neoplasms/eh [Ethnology] | Continental Population Groups | Ethnic Groups | Exercise | Female | Humans | Incidence | Middle Aged | Proportional Hazards Models | Prospective Studies | Surveys and QuestionnairesYear: 2017ISSN:- 0957-5243
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | 28975422 | Available | 28975422 |
CONCLUSIONS: Results from this study do not support an association between sedentary time and breast cancer incidence.
METHODS: The Women's Health Initiative Observational Study is a prospective cohort among women ages 50-79 years at baseline (1994-1998) (analytic cohort=70,233). Baseline questionnaire data were used to estimate time spent sitting and total sedentary time. Associations between time spent sitting and invasive breast cancer incidence overall (n=4,115 cases through September 2015), and by hormone receptor subtypes, were investigated using Cox proportional hazards regression. Analyses were replicated stratified by race/ethnicity, body measurements, and physical activity.
PURPOSE: The objective of this study was to evaluate the prospective association between sedentary time and postmenopausal breast cancer incidence, and whether associations differ by race/ethnicity, physical activity levels, and body measurements.
RESULTS: Among women in this study, 34.5% reported<=5 h/day sitting, 40.9% reported 6-9 h/day and 24.7% reported>=10 h/day. Time spent sitting (>=10 vs. <=5 h/day adjusted HR=1.00, 95% CI 0.92-1.09) was not associated with breast cancer incidence, regardless of hormone receptor subtype. Associations did not differ by race/ethnicity, physical activity, or body measurements.
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