TY - BOOK AU - Fatemi, Omid AU - Goa, Cristobal TI - Improvement in All-Cause Mortality With Blood Pressure Control in a Group of US Veterans With Drug-Resistant Hypertension SN - 1524-6175 KW - *Hypertension/dt [Drug Therapy] KW - *Hypertension/mo [Mortality] KW - *Veterans/sn [Statistics & Numerical Data] KW - Aged KW - Antihypertensive Agents/tu [Therapeutic Use] KW - Blood Pressure Determination/mt [Methods] KW - Blood Pressure/de [Drug Effects] KW - Drug Resistance KW - Female KW - Follow-Up Studies KW - Humans KW - Male KW - Middle Aged KW - Proportional Hazards Models KW - Retrospective Studies KW - United States/ep [Epidemiology] KW - MedStar Heart & Vascular Institute KW - Journal Article N1 - Available online from MWHC library: 2001 - present N2 - The current definition of drug-resistant hypertension includes patients with uncontrolled (URH) (taking >3 antihypertensive medications) and controlled hypertension (CRH; blood pressure [BP] <140/90 mm Hg) (taking >4 medications). The authors hypothesized that all-cause mortality is reduced when URH is controlled. Qualified patients followed at the Washington DC VA Medical Center were included. BPs were averaged for each year of follow-up. In 2006, among 2906 patients who met the criteria for drug-resistant hypertension, 628 had URH. During follow-up, 234 patients were controlled (group 1) and 394 patients remained uncontrolled (group 2). The mortality rate among patients with URH was 28% (110 of 394) and among patients with CRH was 13% (30 of 234), a 54% reduction (P<.01). Multivariate analysis identified independent predictors of mortality as uncontrolled HTN (hazard ratio, 2.5; 95% confidence interval, 1.67-3.75; P<.01), age (hazard ratio, 1.03; 95% confidence interval, 1.01-1.04; P<.01), and diabetes (hazard ratio, 1.46; 95% confidence interval, 1.04-2.05; P<.027). The authors conclude that controlling drug-resistant hypertension markedly reduces all-cause mortality. Copyright © 2015 Wiley Periodicals, Inc UR - http://dx.doi.org/10.1111/jch.12672 ER -