TY  - BOOK
AU  - Dromerick, Alexander W
AU  - Edwardson, Matthew
TI  - Plasma microRNA markers of upper limb recovery following human stroke
SN  - 2045-2322
PY  - 2018///
KW  - *MicroRNAs/bl [Blood]
KW  - *Recovery of Function
KW  - *Stroke/bl [Blood]
KW  - *Stroke/pp [Physiopathology]
KW  - *Upper Extremity/pp [Physiopathology]
KW  - Aged
KW  - Biomarkers/bl [Blood]
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Neuronal Plasticity
KW  - Stroke/ge [Genetics]
KW  - MedStar National Rehabilitation Network
KW  - Journal Article
N2  - Preclinical investigators have implicated several microRNAs as regulators of gene expression promoting neural plasticity following experimental stroke in rodent models. Our goal was to determine whether similar microRNAs might be identifiable in plasma of humans with variable recovery from stroke. Plasma was collected 19 days post-stroke from 27 participants with mild-moderate upper extremity impairment enrolled in the Critical Periods After Stroke Study (CPASS). MicroRNA expression was assessed using TaqMan microRNA assays. Good clinical recovery was defined as >=6 point change in the Action Research Arm Test (ARAT) score from baseline to 6 months, with 22 subjects showing good and 5 showing poor recovery. When comparing the good versus poor recovery groups, six microRNAs showed significantly increased expression - miR-371-3p, miR-524, miR-520g, miR-1255A, miR-453, and miR-583, while 3 showed significantly decreased expression - miR-941, miR-449b, and miR-581. MiR-371-3p and miR-941 have previously been associated with neural repair mechanisms; none of the significant microRNAs have previously been associated with stroke. The 9 microRNAs converge on pathways associated with axonal guidance, developmental biology, and cancer. We conclude that plasma microRNAs may be informative regarding human neural repair mechanisms during stroke recovery and probably differ from those seen in experimental stroke models
UR  - https://dx.doi.org/10.1038/s41598-018-31020-5
ER  -