TY  - BOOK
AU  - Zaaqoq, Akram M
TI  - Hemorrhage, Disseminated Intravascular Coagulopathy, and Thrombosis Complications Among Critically Ill Patients with COVID-19: An International COVID-19 Critical Care Consortium Study
SN  - 0090-3493
PY  - 2023///
KW  - *COVID-19
KW  - *Thrombosis
KW  - Adult
KW  - COVID-19/co [Complications]
KW  - COVID-19/ep [Epidemiology]
KW  - COVID-19/th [Therapy]
KW  - Critical Care
KW  - Critical Illness
KW  - Hemorrhage/ep [Epidemiology]
KW  - Hemorrhage/et [Etiology]
KW  - Humans
KW  - Prospective Studies
KW  - Retrospective Studies
KW  - Thrombosis/ep [Epidemiology]
KW  - Thrombosis/et [Etiology]
KW  - Automated
KW  - MedStar Washington Hospital Center
KW  - Surgery/Surgical Critical Care
KW  - Journal Article
KW  - Observational Study
KW  - Research Support, N.I.H., Extramural
KW  - Research Support, Non-U.S. Gov't
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
N2  - CONCLUSIONS: HECTOR events are frequent complications of severe COVID-19 in ICU patients. Patients receiving ECMO are at particular risk of hemorrhagic complications. Hemorrhagic, but not thrombotic complications, are associated with increased ICU mortality. Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and Wolters Kluwer Health, Inc; DESIGN: Prospective, observational study; INTERVENTIONS: None; MEASUREMENTS AND MAIN RESULTS: HECTOR complications occurred in 1,732 of 11,969 study eligible patients (14%). Acute thrombosis occurred in 1,249 patients (10%), including 712 (57%) with pulmonary embolism, 413 (33%) with myocardial ischemia, 93 (7.4%) with deep vein thrombosis, and 49 (3.9%) with ischemic strokes. Hemorrhagic complications were reported in 579 patients (4.8%), including 276 (48%) with gastrointestinal hemorrhage, 83 (14%) with hemorrhagic stroke, 77 (13%) with pulmonary hemorrhage, and 68 (12%) with hemorrhage associated with extracorporeal membrane oxygenation (ECMO) cannula site. Disseminated intravascular coagulation occurred in 11 patients (0.09%). Univariate analysis showed that diabetes, cardiac and kidney diseases, and ECMO use were risk factors for HECTOR. Among survivors, ICU stay was longer (median days 19 vs 12; p < 0.001) for patients with versus without HECTOR, but the hazard of ICU mortality was similar (hazard ratio [HR] 1.01; 95% CI 0.92-1.12; p = 0.784) overall, although this hazard was identified when non-ECMO patients were considered (HR 1.13; 95% CI 1.02-1.25; p = 0.015). Hemorrhagic complications were associated with an increased hazard of ICU mortality compared to patients without HECTOR complications (HR 1.26; 95% CI 1.09-1.45; p = 0.002), whereas thrombosis complications were associated with reduced hazard (HR 0.88; 95% CI 0.79-0.99, p = 0.03); OBJECTIVES: To determine the prevalence and outcomes associated with hemorrhage, disseminated intravascular coagulopathy, and thrombosis (HECTOR) complications in ICU patients with COVID-19; PATIENTS: Adult patients (>= 16 yr) admitted to participating ICUs for severe COVID-19 from January 1, 2020, to December 31, 2021; SETTING: Two hundred twenty-nine ICUs across 32 countries
UR  - https://dx.doi.org/10.1097/CCM.0000000000005798
ER  -