TY  - BOOK
AU  - Howard, Barbara V
AU  - Umans, Jason G
TI  - Urine arsenic and prevalent albuminuria: evidence  from a population-based study
SN  - 0272-6386
PY  - 2013///
KW  - *Albuminuria/ur [Urine]
KW  - *Arsenic/ur [Urine]
KW  - Aged
KW  - Albuminuria/ep [Epidemiology]
KW  - Cross-Sectional Studies
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - MedStar Health Research Institute
KW  - Journal Article
KW  - Research Support, N.I.H., Extramural
N1  - Available online from MWHC library: 1999 -  present, Available in print through MWHC library: 1999 -  2006
N2  - BACKGROUND: Long-term arsenic exposure is a major  global health problem. However, few epidemiologic studies  have evaluated the association of arsenic with kidney  measures. Our objective was to evaluate the cross-sectional  association between inorganic arsenic exposure and  albuminuria in American Indian adults from rural areas of  Arizona, Oklahoma, and North and South Dakota; CONCLUSIONS: Increasing urine arsenic  concentrations were cross-sectionally associated with  increased albuminuria in a rural US population with a high  burden of diabetes and obesity. Prospective epidemiologic  and mechanistic evidence is needed to understand the role of  arsenic as a kidney disease risk factor. Copyright  2013  National Kidney Foundation, Inc. Published by Elsevier Inc.  All rights reserved; LIMITATIONS: The cross-sectional design cannot  rule out reverse causation; MEASUREMENTS: Arsenic exposure was estimated by  measuring total urine arsenic and urine arsenic species  using inductively coupled plasma mass spectrometry (ICPMS)  and high-performance liquid chromatography-ICPMS,  respectively. Urine albumin was measured by automated  nephelometric immunochemistry; OUTCOMES: Urine albumin-creatinine ratio and  albuminuria status; PREDICTOR: Urine arsenic; RESULTS: The prevalence of albuminuria  (albumin-creatinine ratio >=30 mg/g) was 30%. Median value  for the sum of inorganic and methylated arsenic species was  9.7 (IQR, 5.8-15.6) ug per gram of creatinine.  Multivariable-adjusted prevalence ratios of albuminuria  (albumin-creatinine ratio >=30 mg/g) comparing the 3 highest  to lowest quartiles of the sum of inorganic and methylated  arsenic species were 1.16 (95% CI, 1.00-1.34), 1.24 (95% CI,  1.07-1.43), and 1.55 (95% CI, 1.35-1.78), respectively (P  for trend <0.001). The association between urine arsenic and  albuminuria was observed across all participant subgroups  evaluated and was evident for both micro- and  macroalbuminuria; STUDY DESIGN: Cross-sectional. SETTING &  PARTIPANTS: Strong Heart Study locations in Arizona,  Oklahoma, and North and South Dakota. 3,821 American Indian  men and women aged 45-74 years with urine arsenic and  albumin measurements
UR  - http://dx.doi.org/10.1053/j.ajkd.2012.09.011
ER  -