TY  - BOOK
AU  - Burnett, Mary Susan
AU  - Epstein, Stephen E
TI  - Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis
SN  - 0735-1097
KW  - *Chromosomes, Human, Pair 9/ge [Genetics]
KW  - *Coronary Artery Disease/ge [Genetics]
KW  - Coronary Angiography
KW  - Coronary Artery Disease/ra [Radiography]
KW  - Genetic Loci
KW  - Humans
KW  - Myocardial Infarction/ge [Genetics]
KW  - Polymorphism, Single Nucleotide
KW  - MedStar Health Research Institute
KW  - Journal Article
KW  - Meta-Analysis
KW  - Research Support, N.I.H., Extramural
KW  - Research Support, Non-U.S. Gov't
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007
N2  - BACKGROUND: Chromosome 9p21 variants have been robustly associated with coronary heart disease, but questions remain on the mechanism of risk, specifically whether the locus contributes to coronary atheroma burden or plaque instability; CONCLUSIONS: The 9p21 locus shows convincing association with greater burden of CAD but not with MI in the presence of underlying CAD. This adds further weight to the hypothesis that 9p21 locus primarily mediates an atherosclerotic phenotype. Copyright  2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved; METHODS: We established a collaboration of 21 studies consisting of 33,673 subjects with information on both CAD (clinical or angiographic) and MI status along with 9p21 genotype. Tabular data are provided for each cohort on the presence and burden of angiographic CAD, MI cases with underlying CAD, and the diabetic status of all subjects; OBJECTIVES: This study sought to ascertain the relationship of 9p21 locus with: 1) angiographic coronary artery disease (CAD) burden; and 2) myocardial infarction (MI) in individuals with underlying CAD; RESULTS: We first confirmed an association between 9p21 and CAD with angiographically defined cases and control subjects (pooled odds ratio [OR]: 1.31, 95% confidence interval [CI]: 1.20 to 1.43). Among subjects with angiographic CAD (n = 20,987), random-effects model identified an association with multivessel CAD, compared with those with single-vessel disease (OR: 1.10, 95% CI: 1.04 to 1.17)/copy of risk allele). Genotypic models showed an OR of 1.15, 95% CI: 1.04 to 1.26 for heterozygous carrier and OR: 1.23, 95% CI: 1.08 to 1.39 for homozygous carrier. Finally, there was no significant association between 9p21 and prevalent MI when both cases (n = 17,791) and control subjects (n = 15,882) had underlying CAD (OR: 0.99, 95% CI: 0.95 to 1.03)/risk allele
UR  - http://dx.doi.org/10.1016/j.jacc.2012.10.051
ER  -