TY  - BOOK
AU  - Laughon, S Katherine
TI  - Differences in risk factors for incident and recurrent small-for-gestational-age birthweight: a hospital-based cohort study
SN  - 1470-0328
KW  - *Infant, Small for Gestational Age
KW  - Adolescent
KW  - Adult
KW  - Female
KW  - Humans
KW  - Incidence
KW  - Infant, Newborn
KW  - Middle Aged
KW  - Pregnancy
KW  - Recurrence
KW  - Retrospective Studies
KW  - Risk Factors
KW  - Utah/ep [Epidemiology]
KW  - Young Adult
KW  - MedStar Washington Hospital Center
KW  - Obstetrics and Gynecology, Maternal-Fetal Medicine
KW  - Journal Article
KW  - Research Support, N.I.H., Intramural
N1  - Available online from MWHC library: 1997 - present
N2  - CONCLUSION: There was considerable overlap in the risk factors for SGA recurrence and incidence. Recurrence and incidence risk factors included smoking, short stature, underweight, and inadequate weight gain. Maternal age and hypertensive diseases increased the risk for incidence only. Regardless of the SGA definition, some potentially modifiable risk factors for recurrence were identified. Published 2014. This article is a U.S. Government work and is in the public domain in the USA; DESIGN: Hospital-based cohort study; MAIN OUTCOME MEASURES: Second pregnancy incident (n = 1067) and recurrent SGA (n = 484) determined using a population-based reference; METHODS: Estimated adjusted relative risks (RR) and 95% confidence intervals (95% CI) for the association between second pregnancy characteristics and SGA risk. Tested for risk factor differences between recurrence and incidence (Pdifference); OBJECTIVE: Examine whether small-for-gestational-age (SGA) risk factors differed by prior SGA birth; POPULATION: Electronic medical record data from 25,241 women who were nulliparous at study entry with >2 subsequent consecutive singleton deliveries (2002-2010); RESULTS: SGA complicated 20.3 and 4.5% of deliveries to women with and without a prior SGA birth, respectively. Young maternal age (Pdifference = 0.01) and pregnancy hypertensive diseases (Pdifference = 0.03) were associated with incident but not recurrent SGA. Significant risk factors for incidence and recurrence were smoking (incident RR = 1.64 [95% CI 1.22-2.19]; recurrent RR = 1.59 [95% CI 1.17-2.17]), short stature (incident RR = 1.34 [95% CI 1.16-1.54]; recurrent RR = 1.54 [95% CI 1.31-1.82]), prepregnancy underweight (incident RR = 1.32 [95% CI 1.07-1.64]; recurrent RR = 1.30 [95% CI 1.03-1.64]), and inadequate weight gain (incident RR = 1.41 [95% CI 1.22-1.64]; recurrent RR = 1.33 [95% CI 1.10-1.60]). Race-ethnicity, marital or insurance status, alcohol, diabetes, asthma, thyroid disease, depression, or interpregnancy interval were not associated with incidence or recurrence; SETTING: Utah, USA
UR  - http://dx.doi.org/10.1111/1471-0528.12628
ER  -