TY  - BOOK
AU  - Dolman, Sarahfaye F
AU  - Kolm, Paul
AU  - Weintraub, William S
TI  - 3-Dimensional Strain Analysis of Hypertrophic Cardiomyopathy: Insights From the NHLBI International HCM Registry
SN  - 1876-7591
KW  - *Cardiomyopathy, Hypertrophic
KW  - *Contrast Media
KW  - Biomarkers
KW  - Female
KW  - Gadolinium
KW  - Humans
KW  - Magnetic Resonance Imaging, Cine
KW  - National Heart, Lung, and Blood Institute (U.S.)
KW  - Predictive Value of Tests
KW  - Registries
KW  - Stroke Volume
KW  - United States
KW  - Ventricular Function, Left
KW  - Automated
KW  - MedStar Health Research Institute
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
N2  - BACKGROUND: Abnormal global longitudinal strain (GLS) has been independently associated with adverse cardiac outcomes in both obstructive and nonobstructive hypertrophic cardiomyopathy; CONCLUSIONS: Abnormal strain in hypertrophic cardiomyopathy is associated with other imaging and serum biomarkers of increased risk. Further follow-up of the HCMR cohort is needed to understand the independent relationship between LV strain and adverse cardiac outcomes in hypertrophic cardiomyopathy. Copyright � 2022. Published by Elsevier Inc; METHODS: The study evaluated comprehensive three-dimensional left ventricular myocardial strain from cine cardiac magnetic resonance in 2,311 patients from HCMR using in-house validated feature-tracking software. These data were correlated with other imaging markers, serum biomarkers, and demographic variables; OBJECTIVES: The goal of this study was to understand predictors of abnormal GLS from baseline data from the National Heart, Lung, and Blood Institute (NHLBI) Hypertrophic Cardiomyopathy Registry (HCMR); RESULTS: Abnormal median GLS (> -11.0%) was associated with higher left ventricular (LV) mass index (93.8 +/- 29.2 g/m2 vs 75.1 +/- 19.7 g/m2; P < 0.0001) and maximal wall thickness (21.7 +/- 5.2 mm vs 19.3 +/- 4.1 mm; P < 0.0001), lower left (62% +/- 9% vs 66% +/- 7%; P < 0.0001) and right (68% +/- 11% vs 69% +/- 10%; P < 0.01) ventricular ejection fractions, lower left atrial emptying functions (P < 0.0001 for all), and higher presence and myocardial extent of late gadolinium enhancement (6 SD and visual quantification; P < 0.0001 for both). Elastic net regression showed that adjusted predictors of GLS included female sex, Black race, history of syncope, presence of systolic anterior motion of the mitral valve, reverse curvature and apical morphologies, LV ejection fraction, LV mass index, and both presence/extent of late gadolinium enhancement and baseline N-terminal pro-B-type natriuretic peptide and troponin levels
UR  - https://dx.doi.org/10.1016/j.jcmg.2022.10.005
ER  -