TY  - BOOK
AU  - Scott, Rachel
TI  - Translating Clinical Pharmacology Data in Pregnancy to Evidence-Based Guideline Recommendations: Perspectives From the HIV Field. [Review]
SN  - 0091-2700
PY  - 2023///
KW  - *HIV Infections
KW  - *Pharmacology, Clinical
KW  - Breast Feeding
KW  - Female
KW  - Fetus
KW  - HIV Infections/dt [Drug Therapy]
KW  - Humans
KW  - Infant
KW  - Lactation
KW  - Pregnancy
KW  - Automated
KW  - MedStar Washington Hospital Center
KW  - Obstetrics and Gynecology
KW  - Journal Article
KW  - Review
N1  - Available online from MWHC library: 1999 - present, Available in print through MWHC library: 1999 - 2006
N2  - Pharmacokinetic (PK) studies in pregnant, postpartum, and breastfeeding people are critical to informing appropriate medication use and dosing. A key component of translating PK results in these complex populations into clinical practice involves the systematic review and interpretation of data by guideline panels, composed of clinicians, scientists, and community members, to leverage available data for informed decision making by clinicians and patients and offer clinical best practices. Interpretation of PK data in pregnancy involves evaluation of multiple factors such as the study design, target population, and type of sampling performed. Assessments of fetal and infant drug exposure while in utero or during breastfeeding, respectively, are also critical for informing whether medications are safe to use during pregnancy and throughout postpartum in lactating people. This review will provide an overview of this translational process, discussion of the various factors considered by guideline panels, and practical aspects of implementing certain recommendations, using the HIV field as an example. Copyright © 2023, The American College of Clinical Pharmacology
UR  - https://dx.doi.org/10.1002/jcph.2240
ER  -