TY  - BOOK
AU  - Jenkins, Chuka B
TI  - Prediction of preeclampsia utilizing the first trimester screening examination
SN  - 0002-9378
PY  - 2014///
KW  - *Hypertension/ep [Epidemiology]
KW  - *Pre-Eclampsia/di [Diagnosis]
KW  - *Pregnancy Complications, Cardiovascular/ep [Epidemiology]
KW  - *Pregnancy in Diabetics/ep [Epidemiology]
KW  - *Uterine Artery/us [Ultrasonography]
KW  - Adolescent
KW  - Adult
KW  - Area Under Curve
KW  - Biomarkers/bl [Blood]
KW  - Blood Pressure
KW  - Cohort Studies
KW  - Female
KW  - Humans
KW  - Logistic Models
KW  - Parity
KW  - Pre-Eclampsia/bl [Blood]
KW  - Pre-Eclampsia/us [Ultrasonography]
KW  - Pregnancy
KW  - Pregnancy Trimester, First/bl [Blood]
KW  - Pregnancy-Associated Plasma Protein-A/me [Metabolism]
KW  - Prenatal Diagnosis
KW  - Prognosis
KW  - Prospective Studies
KW  - Risk Assessment
KW  - Ultrasonography, Prenatal
KW  - Young Adult
KW  - MedStar Franklin Square Medical Center
KW  - MedStar Harbor Hospital
KW  - Obstetrics and Gynecology
KW  - Journal Article
KW  - Research Support, Non-U.S. Gov't
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006
N2  - CONCLUSION: First trimester prediction rules using parameters currently available at first trimester screening identify a significant proportion of women with subsequent preeclampsia.Copyright © 2014 Elsevier Inc. All rights reserved; OBJECTIVE: To derive a prediction rule for preeclampsia and early onset preeclampsia requiring delivery <34 weeks using first trimester maternal, ultrasound, and serum markers; RESULTS: In 2441 women, 108 (4.4%) women developed preeclampsia, and 18 (0.7%) early preeclampsia. Nulliparity, prior hypertension, diabetes, prior preeclampsia, mean arterial pressure, and the log pregnancy-associate pregnancy protein-A multiples of the median were primary risk factors. Prediction rules for preeclampsia/early preeclampsia had an area under the curve of 0.82/0.83 respectively. Preeclampsia was predicted with 49% sensitivity and early preeclampsia with 55% sensitivity for a 10% false positive rate; STUDY DESIGN: Prospective cohort study of women enrolled at first trimester screening. Maternal history, demographics, anthropometry, ultrasound parameters, and serum analytes were compared between women with preeclampsia and normal outcome. The prediction rule was derived by Lasso logistic regression analysis
UR  - http://dx.doi.org/10.1016/j.ajog.2014.04.018
ER  -