TY  - BOOK
AU  - Burman, Kenneth D
AU  - Jonklaas, Jacqueline
AU  - Sathasivam, Anpalakan
AU  - Wang, Hong
TI  - 3,3'-Diiodothyronine concentrations in hospitalized or thyroidectomized patients: results from a pilot study
SN  - 1530-891X
PY  - 2014///
KW  - *Diiodothyronines/bl [Blood]
KW  - *Thyroidectomy
KW  - Adult
KW  - Aged
KW  - Female
KW  - Hospitalization
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Pilot Projects
KW  - Tandem Mass Spectrometry
KW  - Triiodothyronine/bl [Blood]
KW  - MedStar Health Research Institute
KW  - MedStar Washington Hospital Center
KW  - Medicine/Endocrinology
KW  - Journal Article
KW  - Research Support, N.I.H., Extramural
N2  - CONCLUSION: We observed associations between inpatient status and reduced 3,3'-T2 concentrations. This appears to be a global change associated with illness, rather than an association with specific medical conditions. We also observed higher 3,3'-T2 concentrations in athyreotic outpatients receiving thyroid-stimulating hormone (TSH) suppression therapy. This demonstrates that there is production of 3,3'-T2 from levothyroxine (LT4) in extrathyroidal tissues. Conversion of thyroxine (T4) to 3,3'-T2 via both triiodothyronine (T3) and reverse triiodothyronine (rT3) pathways may prevent excessive T3 concentrations in such patients; METHODS: A total of 100 patients who were recruited from a group of inpatients and outpatients with a diverse range of medical conditions, donated a single blood sample that was assayed for thyroid hormone derivatives using liquid-chromatography tandem mass spectrometry (LC-MS/MS). The associations between 3,3'-T2 concentrations and physiologic data and medical conditions were assessed; OBJECTIVE: To determine if various medical conditions affect the serum concentrations of 3,3'-diiodothyronine (3,3'-T2); RESULTS: Higher quartiles of 3,3'-T2 concentrations (quartile 1: 2.01-7.48, quartile 2: 7.74-12.4, quartile 3: 12.5-17, quartile 4: 17.9-45.8 pg/mL) were associated with decreasing occurrence of critical illness (58%, 11%, 0%, 8%), stroke (29%, 7.7%, 4%, 0%), critical care unit hospitalization (75%, 39%, 8.3 %, 12%), and inpatient status (83%, 42%, 8%, 12%) (all P<.001). The same quartiles were associated with increasing frequency of thyroidectomy (4%, 12%, 17%, 60%). In multivariate analyses, after adjustment for age and sex, inpatient status was associated with decreasing concentrations of 3,3'-T2 (46% decrease for inpatients with 95% confidence interval [CI] 32-57%, P<.0001). Thyroidectomy was associated with increasing concentrations of 3,3'-T2 (29% increase (CI 0.5-66%, P = .049)
UR  - http://dx.doi.org/10.4158/EP13453.OR
ER  -