TY  - BOOK
AU  - Ben-Dor, Itsik
AU  - Didier, Romain
AU  - Escarcega, Ricardo O
AU  - Gai, Jiaxing
AU  - Kiramijyan, Starkis
AU  - Koifman, Edward
AU  - Minha, Sa'ar
AU  - Negi, Smita I
AU  - Okubagzi, Petros
AU  - Pichard, Augusto D
AU  - Satler, Lowell F
AU  - Torguson, Rebecca
AU  - Waksman, Ron
TI  - Body mass index association with survival in severe aortic stenosis patients undergoing transcatheter aortic valve replacement
SN  - 1522-1946
PY  - 2016///
KW  - *Aortic Valve
KW  - *Aortic Valve Stenosis/th [Therapy]
KW  - *Body Mass Index
KW  - *Cardiac Catheterization
KW  - *Heart Valve Prosthesis Implantation
KW  - *Obesity/co [Complications]
KW  - Aged
KW  - Aged, 80 and over
KW  - Aortic Valve Stenosis/co [Complications]
KW  - Aortic Valve Stenosis/dg [Diagnostic Imaging]
KW  - Aortic Valve Stenosis/mo [Mortality]
KW  - Aortic Valve/dg [Diagnostic Imaging]
KW  - Aortic Valve/pp [Physiopathology]
KW  - Cardiac Catheterization/ae [Adverse Effects]
KW  - Cardiac Catheterization/mo [Mortality]
KW  - Catheterization, Peripheral
KW  - Chi-Square Distribution
KW  - District of Columbia
KW  - Female
KW  - Femoral Artery
KW  - Frail Elderly
KW  - Geriatric Assessment
KW  - Heart Valve Prosthesis Implantation/ae [Adverse Effects]
KW  - Heart Valve Prosthesis Implantation/mo [Mortality]
KW  - Humans
KW  - Kaplan-Meier Estimate
KW  - Male
KW  - Multivariate Analysis
KW  - Obesity/di [Diagnosis]
KW  - Obesity/mo [Mortality]
KW  - Proportional Hazards Models
KW  - Retrospective Studies
KW  - Risk Factors
KW  - Severity of Illness Index
KW  - Time Factors
KW  - Treatment Outcome
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
N1  - Available online from MWHC library: 1996 - present, Available in print through MWHC library: 1996 - 2006
N2  - BACKGROUND: Conflicting results have been reported regarding impact of body mass index (BMI) on outcome of transcatheter aortic valve replacement (TAVR) patients. This study evaluates the impact of BMI on 1 year mortality in patients undergoing TAVR via the transfemoral (TF) access; CONCLUSIONS: BMI <20 kg/m(2) should be considered a frailty marker during the screening process of severe AS TAVR patients as it is associated with higher mortality, while obesity confers similar mortality risk as normal weight. � 2015 Wiley Periodicals, Inc; Copyright � 2015 Wiley Periodicals, Inc; METHODS: Aortic stenosis (AS) patients undergoing TAVR via a TF access between May 2007 and December 2014 were categorized to 4 groups by BMI: low (<20), normal (20-24.9), overweight (25-30), and obese (>30). Baseline parameters were compared, and multivariate Cox proportional hazard regression models were generated to assess outcome differences; RESULTS: Among 491 severe AS TAVR patients, 43 had low BMI, 148 had normal BMI, 162 were overweight, and 138 were obese. Obese patients were younger with lower Society of Thoracic Surgeons scores and higher rates of preserved ejection fraction and diabetes. There was a higher rate of women in the BMI extremes. Aortic valve area was higher among obese patients; however, the indexed area was inversely correlated with BMI. Vascular complications and transfusions were more common in the low-BMI group, while acute kidney injury was more common in obese patients. All-cause mortality at 1 year was higher in the low-BMI group (log-rank p=0.003) with no significant difference among normal and above-normal BMI patients. In a multivariate model, BMI <20 kg/m(2) was an independent predictor of mortality (HR=2.45, p=0.01)
UR  - https://dx.doi.org/10.1002/ccd.26377
ER  -