TY  - BOOK
AU  - Howard, Barbara V
TI  - Impact of biological aging on arterial aging in American Indians: findings from the Strong Heart Family Study
SN  - 1945-4589
PY  - 2016///
KW  - *Aging/ph [Physiology]
KW  - *Models, Cardiovascular
KW  - *Telomere Homeostasis/ph [Physiology]
KW  - *Vascular Stiffness/ph [Physiology]
KW  - Adolescent
KW  - Adult
KW  - Age Factors
KW  - Aged
KW  - Aged, 80 and over
KW  - Alcohol Drinking
KW  - Biomarkers
KW  - Blood Glucose/an [Analysis]
KW  - Blood Pressure/ph [Physiology]
KW  - Body Mass Index
KW  - Cross-Sectional Studies
KW  - Exercise
KW  - Female
KW  - Humans
KW  - Indians, North American
KW  - Leukocytes/me [Metabolism]
KW  - Life Style
KW  - Lipids/bl [Blood]
KW  - Male
KW  - Middle Aged
KW  - Risk Factors
KW  - Sex Factors
KW  - Smoking
KW  - Young Adult
KW  - MedStar Health Research Institute
KW  - Journal Article
N2  - Telomere length, a marker of biological aging, has been associated with cardiovascular disease (CVD). Increased arterial stiffness, an indicator of arterial aging, predicts adverse CVD outcomes. However, the relationship between telomere length and arterial stiffness is less well studied. Here we examined the cross-sectional association between leukocyte telomere length (LTL) and arterial stiffness in 2,165 American Indians in the Strong Heart Family Study (SHFS). LTL was measured by qPCR. Arterial stiffness was assessed by stiffness index beta. The association between LTL and arterial stiffness was assessed by generalized estimating equation model, adjusting for sociodemographics (age, sex, education level), study site, metabolic factors (fasting glucose, lipids, systolic blood pressure, and kidney function), lifestyle (BMI, smoking, drinking, and physical activity), and prevalent CVD. Results showed that longer LTL was significantly associated with a decreased arterial stiffness (beta=-0.070, P=0.007). This association did not attenuate after further adjustment for hsCRP (beta=-0.071, P=0.005) or excluding participants with overt CVD (beta=-0.068, P=0.012), diabetes (beta=-0.070, P=0.005), or chronic kidney disease (beta=-0.090, P=0.001). In summary, shorter LTL was significantly associated with an increased arterial stiffness, independent of known risk factors. This finding may shed light on the potential role of biological aging in arterial aging in American Indians
UR  - https://dx.doi.org/10.18632/aging.101013
ER  -