TY  - BOOK
AU  - Boyce, Steven W
TI  - Patients Awaiting Heart Transplantation on HVAD Support for Greater Than 2 Years
SN  - 1058-2916
PY  - 2016///
KW  - *Heart Transplantation
KW  - *Heart-Assist Devices
KW  - Adult
KW  - Aged
KW  - Female
KW  - Heart Failure/th [Therapy]
KW  - Heart-Assist Devices/ae [Adverse Effects]
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
N1  - Available online from MWHC library: 2000 - present, Available in print through MWHC library: 1999 - 2003
N2  - Advanced heart failure patients who are classified as bridge to transplant (BTT) often remain on mechanical circulatory support (MCS) for long durations because of the limited supply of donor organs. Here, we present the outcomes of patients who have been supported by the HeartWare ventricular assist device system for more than 2 years. In the HeartWare BTT and continued access protocol trial, 74 of the 382 total patients (19.4%) had more than 2 years of MCS with a mean time of 1,045 days on device. The long-term group was more frequently female, was nonwhite, and had Interagency Registry for Mechanically Assisted Circulatory Support profiles 4-7. Postimplant adverse event rates including bleeding, cardiac arrhythmia, infection, stroke, renal dysfunction, and right heart failure were less frequent in the long-term cohort. In addition, the long-term cohort displayed significant improvements in Kansas City Cardiomyopathy Questionnaire Overall Summary Score, EuroQOL-5D Overall Health State Score, and 6 minute walk scores from baseline values. The rate of heart transplantation was lower for the long-term cohort, which may have been a result of their sex and blood type. However, most of these patients are still listed for cardiac transplantation and maintained their quality of life profiles through 3 years of support
UR  - https://dx.doi.org/10.1097/MAT.0000000000000380
ER  -