TY  - BOOK
AU  - Miller, Kristen
TI  - Not all organ dysfunctions are created equal - Prevalence and mortality in sepsis
SN  - 0883-9441
PY  - 2018///
KW  - *Multiple Organ Failure/ep [Epidemiology]
KW  - *Sepsis/ep [Epidemiology]
KW  - Adult
KW  - Aged
KW  - Delaware/ep [Epidemiology]
KW  - Female
KW  - Hospital Mortality
KW  - Humans
KW  - Logistic Models
KW  - Male
KW  - Middle Aged
KW  - Multiple Organ Failure/mo [Mortality]
KW  - Odds Ratio
KW  - Prevalence
KW  - Retrospective Studies
KW  - Risk Factors
KW  - Sepsis/mo [Mortality]
KW  - MedStar Institute for Innovation
KW  - Journal Article
N1  - Available online through MWHC library: 2012 - present
N2  - CONCLUSION: There exist differences in measures of organ dysfunction occurrence and their association with mortality. These findings support increased clinical efforts to identify sepsis patients to inform diagnostic decisions; Copyright (c) 2018 Elsevier Inc. All rights reserved; MATERIALS AND METHODS: Descriptive and multivariate analyses of retrospective data including patients (age>=18years) hospitalized at the study hospital from July 2013 to April 2016 who met the criteria for an infection visit (62,057 unique visits); PURPOSE: While organ dysfunctions within sepsis have been widely studied, interaction between measures of organ dysfunction remains an understudied area. The objective of this study is to quantify the impact of organ dysfunction on in-hospital mortality in infected population; RESULTS: The multivariate logistic regression model had an area under the curve of 0.9. Highest odds ratio (OR) associated with increased mortality risk was identified as fraction of inspired oxygen (FiO<sub>2</sub>)>21% (OR=5.8 and 95% Confidence Interval (CI) 1.8-35.6), and elevated lactate >2.0mmol/L (OR=2.45 (95% CI=2.1-2.8)). Most commonly observed measures of organ dysfunction within mortality visits included elevated lactate (> 2.0mmol/L), mechanical ventilation, and oxygen saturation (SpO<sub>2</sub>)/FiO<sub>2</sub> ratio (< 421) at least once within 48h prior to or 24h after anti-infective administration
UR  - https://dx.doi.org/10.1016/j.jcrc.2018.08.021
ER  -