TY  - BOOK
AU  - Al-Shbool, Ghassan
AU  - Barac, Ana
AU  - Basyal, Binaya
AU  - Desale, Sameer
AU  - Kashyap, Kartikeya-
AU  - Zaghlol, Raja
TI  - Usefulness of Malignancy as a Predictor of WorseIn-Hospital  Outcomes in Patients With Takotsubo Cardiomyopathy
SN  - 0002-9149
PY  - 2019///
KW  - *Hospitalization
KW  - *Neoplasms/ep [Epidemiology]
KW  - *Risk Assessment/mt [Methods]
KW  - *Takotsubo Cardiomyopathy/di [Diagnosis]
KW  - Aged
KW  - Coronary Angiography
KW  - Echocardiography
KW  - Electrocardiography
KW  - Female
KW  - Follow-Up Studies
KW  - Hospital Mortality/td [Trends]
KW  - Humans
KW  - Male
KW  - Neoplasms/co [Complications]
KW  - Prevalence
KW  - Prognosis
KW  - Retrospective Studies
KW  - Risk Factors
KW  - Survival Rate/td [Trends]
KW  - Takotsubo Cardiomyopathy/ep [Epidemiology]
KW  - Takotsubo Cardiomyopathy/et [Etiology]
KW  - United States/ep [Epidemiology]
KW  - MedStar Health Research Institute
KW  - MedStar Heart & Vascular Institute
KW  - Medicine/Internal Medicine
KW  - Journal Article
N1  - Available online from MWHC library: 1995 - present,  Available in print through MWHC library: 1999 - 2006
N2  - Copyright (c) 2018. Published by Elsevier Inc; Takotsubo cardiomyopathy (TC) is a form of dilated  cardiomyopathy often associated with physical or emotional stress.  Association with cancer has been reported, however, in-hospital  outcomes in TC patients with history of malignancy have not been fully  characterized. We conducted a retrospective chart review of  hospitalized patients with diagnosis of TC between January 2006 and  January 2017. Patients were divided into 2 groups based on the  previous history of malignancy. Presenting symptoms, cardiac imaging  and short-term events including in-hospital complications and  mortality, were compared. Of 318 patients with TC, 81 (25.4%) had a  previous diagnosis of cancer. Mean age was 67.5 (SD 12.6), 151 (47.5%)  were African American, 122 (38.4%) Caucasian, and 10 (3.1%) of other  ethnicities. Patients with history of malignancy were older (70.0 [SD  10.6] vs 66.6 [SD 13.1] years, p=0.03), had higher heart rate on  presentation (93 [SD 19] vs 87 [SD 25] beats/minute, p=0.03), higher  prevalence of severely decreased cardiac function (left ventricular  ejection fraction <25%) (29.6% vs 16%, p=0.01), longer hospitalization  (7 (4-13) vs 4 (3-8) days, p=0.001) and experienced more in-hospital  cardiac arrests (6 [7.4%] vs 5 [2.1%], p=0.035) compared with patients  without malignancy history. Higher percentage of longer  hospitalization and left ventricular ejection fraction <25% in the  cancer group persisted after controlling for sepsis, chemotherapy  exposure, and metastatic disease. In conclusion, in a racially diverse  hospitalized population of TC, prevalence of cancer history is high,  and diagnosis of previous malignancy is associated with adverse in- hospital outcomes
UR  - https://dx.doi.org/10.1016/j.amjcard.2018.11.054
ER  -