TY  - BOOK
AU  - Gill, Gauravpal S
TI  - Prior Heart Failure Hospitalization and Outcomes in Patients with Heart Failure with Preserved and Reduced Ejection Fraction
SN  - 0002-9343
PY  - 2020///
KW  - *Heart Failure/th [Therapy]
KW  - *Hospitalization/sn [Statistics & Numerical Data]
KW  - *Mortality
KW  - *Patient Readmission/sn [Statistics & Numerical Data]
KW  - *Stroke Volume
KW  - Aged
KW  - Aged, 80 and over
KW  - Case-Control Studies
KW  - Cause of Death
KW  - Female
KW  - Heart Failure/pp [Physiopathology]
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Prognosis
KW  - Propensity Score
KW  - Proportional Hazards Models
KW  - Registries
KW  - MedStar Washington Hospital Center
KW  - Medicine/Internal Medicine
KW  - Journal Article
N1  - Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - present
N2  - BACKGROUND: A prior hospitalization due to heart failure is associated with poor outcomes in ambulatory patients with heart failure. Less is known about this association in hospitalized patients with heart failure and whether it varies by ejection fraction; CONCLUSIONS: Among hospitalized patients with heart failure, a prior heart failure hospitalization is associated with higher risks of mortality and readmission in both HFpEF and HFrEF. The relative risks of death and heart failure readmission appear to be higher in HFpEF than in HFrEF; Copyright (c) 2019. Published by Elsevier Inc; METHODS: Of the 25,345 hospitalized patients in Medicare-linked OPTIMIZE-HF registry, 22,491 had known heart failure, of whom 7648 and 9558 had heart failure with preserved (>=50%) and reduced (<=40%) ejection fraction (HFpEF and HFrEF), respectively. Overall, 927 and 1862 patients with HFpEF and HFrEF had heart failure hospitalizations during six months before the index hospitalization, respectively. Using propensity scores for prior heart failure hospitalization, we assembled two matched cohorts of 924 pairs and 1844 pairs of patients with HFpEF and HFrEF, respectively, each balanced for 58 baseline characteristics. Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes during six years of follow-up; RESULTS: Among 1848 matched patients with HFpEF, HRs (95% CIs) for all-cause mortality, all-cause readmission and heart failure readmission were 1.35 (1.21-1.50; p<0.001), 1.34 (1.21-1.47; p<0.001) and 1.90 (1.67-2.16; p<0.001), respectively. Respective HRs (95% CIs) in 3688 matched patients with HFrEF were 1.17 (1.09-1.26; p<0.001), 1.32 (1.23-1.41; p<0.001), and 1.48 (1.37-1.61; p<0.001)
UR  - https://dx.doi.org/10.1016/j.amjmed.2019.06.040
ER  -