TY  - BOOK
AU  - Ahmed, Sara
AU  - Chou, Jiling
AU  - Ghazzal, Amre
AU  - Hofmeyerv, Mark
AU  - Kadakkal, Ajay
AU  - Lam, Phillip H
AU  - Molina, Ezequiel
AU  - Najjar, Samer S
AU  - Radwan, Sohab
AU  - Rao, Sriram D
AU  - Rodrigo, Maria
AU  - Sheikh, Farooq
AU  - Weintraub, William S
AU  - Zaghlol, Louay
AU  - Zaghlol, Raja
TI  - Beta-blockers and Ambulatory Inotropic Therapy
SN  - 1071-9164
PY  - 2022///
KW  - IN PROCESS -- NOT YET INDEXED
KW  - MedStar Health Research Institute
KW  - MedStar Heart & Vascular Institute
KW  - Internal Medicine Residency
KW  - MedStar Georgetown University Hospital/MedStar Washington Hospital Center
KW  - Journal Article
N2  - BACKGROUND: Continuous infusion of ambulatory inotropic therapy (AIT) is increasingly used in patients with end stage heart failure (HF). There is a paucity of data on the concomitant use of beta blockers (BB) in these patients; CONCLUSION: In patients with end-stage heart failure on AIT, the use of BB with inotropes was associated with lower HF hospitalizations and ventricular arrhythmias. Copyright © 2022. Published by Elsevier Inc; METHODS: We retrospectively reviewed all patients discharged from our institution on AIT. The cohort was stratified into two groups based on BB use. The 2 groups were compared for differences in HF hospitalizations, ventricular arrhythmias, and ICD therapies (shock or anti-tachycardia pacing); RESULTS: Between 2010 and 2017, 349 patients were discharged on AIT (95% on Milrinone), 74% were males with a mean age of 61 +/-14 years. BB were used in 195 (56%) patients, whereas 154 (44%) did not receive these medications. Patients in the BB-group had longer duration of AIT support compared to those in the non-BB group (141 [1-2114] vs. 68 [1-690] days). After adjusting for differences in baseline characteristics and indication for AIT, patients in the BB-group had significantly lower rates of HF-hospitalizations (hazard ratio (HR) 0.61 [0.43-0.86], p= 0.005), ventricular arrhythmias (HR 0.34 [0.15-0.74], p=0.007)and ICD therapies (HR 0.24 [0.07-0.79], p=0.02)
UR  - https://dx.doi.org/10.1016/j.cardfail.2022.03.352
ER  -