Gastrointestinal Bleeding among Hospitalizations for Salicylate Poisoning in the United States. 

 -  2021 
<br/><br/>Available online from MWHC library: 1995 - present 
<br/><br/> BACKGROUND: This study aimed to determine the incidence, as well as evaluate risk factors, and impact of gastrointestinal bleeding on outcomes and resource use in patients admitted for salicylate poisoning.  CONCLUSION: Gastrointestinal bleeding occurred in about 4% of patients admitted for salicylate poisoning. Gastrointestinal bleeding was associated with higher morbidity and resource use but not mortality. Copyright (c) The Author(s) 2021. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oup.com.  METHODS: We used the National Inpatient Sample to construct a cohort of patients hospitalized primarily for salicylate poisoning from 2003-2014. We compared clinical characteristics, in-hospital treatments, outcomes, and resource use between salicylate poisoning patients with and without gastrointestinal bleeding.  RESULTS: Of 13,805 hospital admissions for salicylate poisoning, gastrointestinal bleeding occurred in 482 (3.5%) admissions. The risk factors for gastrointestinal bleeding included older age, history of atrial fibrillation, and cirrhosis. After adjusting for difference in baseline characteristics, patients with gastrointestinal bleeding required more gastric lavage, gastrointestinal endoscopy, invasive mechanical ventilation, red blood cell transfusion. Gastrointestinal bleeding was significantly associated with increased risk of anemia, circulatory, liver, and hematological failure but was not significantly associated with increased in-hospital mortality. The length of hospital stay and hospitalization cost was significantly higher in patients with gastrointestinal bleeding. 
<br/><br/><br/>English 
<br/><br/><label>ISSN: </label>1460-2393 
<br/><br/><label>Standard No.: </label>10.1093/qjmed/hcab034 [doi] 6143038 [pii] 
<br/><br/><label>Subjects--Topical Terms: </label><br/>*Gastrointestinal Hemorrhage<br/>*Hospitalization<br/>Databases, Factual<br/>Gastrointestinal Hemorrhage/ci [Chemically Induced]<br/>Hospital Mortality<br/>Humans<br/>Retrospective Studies<br/>Salicylates<br/>United States
<br/><br/><label>Subjects--Geographic Terms: </label><br/>MedStar Washington Hospital Center
<br/><br/><label>Index Terms--Occupation: </label><br/>Medicine/Gastroenterology
<br/><br/><label>Index Terms--Function: </label><br/>Journal Article