TY  - BOOK
AU  - Armonda, Rocco A
AU  - Aulisi, Edward
AU  - Chang, Jason J
AU  - Dowlati, Ehsan
AU  - Felbaum, Daniel R
AU  - Kalegha, Enite
TI  - Admission Neutrophil to Lymphocyte Ratio for Predicting Outcome in Subarachnoid Hemorrhage
SN  - 1052-3057
PY  - 2021///
KW  - *Lymphocytes/im [Immunology]
KW  - *Neutrophils/im [Immunology]
KW  - *Patient Admission
KW  - *Subarachnoid Hemorrhage/di [Diagnosis]
KW  - Adult
KW  - Aged
KW  - Biomarkers/bl [Blood]
KW  - Disability Evaluation
KW  - Female
KW  - Humans
KW  - Lymphocyte Count
KW  - Male
KW  - Middle Aged
KW  - Patient Discharge
KW  - Predictive Value of Tests
KW  - Prognosis
KW  - Retrospective Studies
KW  - Subarachnoid Hemorrhage/im [Immunology]
KW  - Subarachnoid Hemorrhage/pp [Physiopathology]
KW  - Subarachnoid Hemorrhage/th [Therapy]
KW  - United States
KW  - MedStar Washington Hospital Center
KW  - Neurosurgery
KW  - Neurosurgery Residency
KW  - Nursing
KW  - Radiology
KW  - Surgery/Surgical Critical Care
KW  - Journal Article
N2  - CONCLUSIONS: Higher admission NLR is an independent predictor for poor functional outcome at discharge in aSAH patients. The evaluation of anti-inflammatory targets in the future may allow for improved functional outcome after aSAH. Copyright (c) 2021 Elsevier Inc. All rights reserved; MATERIAL AND METHODS: Consecutive patients with aSAH were treated at two tertiary stroke centers during a five-year period. Functional outcome was defined as discharge modified Rankin score dichotomized at scores 0-2 (good) vs. 3-6 (poor); PURPOSE: We sought to evaluate the relationship between admission neutrophil-to-lymphocyte ratio (NLR) and functional outcome in aneurysmal subarachnoid hemorrhage (aSAH) patients; RESULTS: 474 aSAH patients were evaluated with a mean NLR 8.6 (SD 8.3). In multivariable logistic regression analysis, poor functional outcome was independently associated with higher NLR, older age, poorer clinical status on admission, prehospital statin use, and vasospasm. Increasing NLR analyzed as a continuous variable was independently associated with higher odds of poor functional outcome (OR 1.03, 95%CI 1.00-1.07, p=0.05) after adjustment for potential confounders. When dichotomized using ROC curve analysis, a threshold NLR value of greater than 6.48 was independently associated with higher odds of poor functional outcome (OR 1.71, 95%CI 1.07-2.74, p=0.03) after adjustment for potential confounders
UR  - https://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2021.105936
ER  -