TY  - BOOK
AU  - Brummel-Ziedins, Kathleen E
AU  - Johnson, Laura
AU  - Keyloun, John
AU  - Mclawhorn, Melissa M
AU  - Moffatt, Lauren T
AU  - Shupp, Jeffrey W
TI  - Inhalation Injury is Associated with Endotheliopathy and Abnormal Fibrinolytic Phenotypes in Burn Patients: A Cohort Study
SN  - 1559-047X
PY  - 2022///
KW  - *Burns
KW  - Burns/co [Complications]
KW  - Cohort Studies
KW  - Female
KW  - Humans
KW  - Male
KW  - Phenotype
KW  - Retrospective Studies
KW  - Thrombelastography
KW  - MedStar Health Research Institute
KW  - MedStar Washington Hospital Center
KW  - Burn Research Fellowship
KW  - Firefighters' Burn and Surgical Research Laboratory
KW  - Surgery/Burn Services
KW  - Journal Article
N1  - Available online through MWHC library: 2006 - present, Available in print through MWHC library: 2006 - present
N2  - Burn injury is associated with endothelial dysfunction and coagulopathy and concomitant inhalation injury increases morbidity and mortality. The aim of this work is to identify associations between inhalation injury (IHI), coagulation homeostasis, vascular endothelium, and clinical outcomes in burn patients. One-hundred and twelve patients presenting to a regional burn center were included in this retrospective cohort study. Whole blood was collected at set intervals from admission through 24 hours and underwent viscoelastic assay with rapid TEG (rTEG). Syndecan-1 (SDC-1) on admission was quantified by ELISA. Patients were grouped by the presence (n=28) or absence (n=84) of concomitant IHI and rTEG parameters, fibrinolytic phenotypes, SDC-1, and clinical outcomes were compared. Of the 112 thermally injured patients, 28 (25%) had IHI. Most patients were male (68.8%) with a median age of 40 (IQR, 29-57) years. Patients with IHI had higher overall mortality (42.68% vs. 8.3%; p<0.0001). rTEG LY30 was lower in patients with IHI at hours 4 and 12 (p<0.05). There was a pattern of increased abnormal fibrinolytic phenotypes among IHI patients. There was a greater proportion of IHI patients with endotheliopathy (SDC-1 > 34 ng/mL) (64.7% vs. 26.4%; p=0.008). There was a pattern of increased mortality among patients with inhalation injury and endotheliopathy (0% vs. 72.7%; p=0.004). Significant differences between patients with and without IHI were found in measures assessing fibrinolytic potential and endotheliopathy. Mortality was associated with abnormal fibrinolysis, endotheliopathy, and inhalation injury. However, the extent to which IHI associated dysfunction is independent of TBSA burn size remains to be elucidated. Copyright (c) The Author(s) 2021. Published by Oxford University Press on behalf of the American Burn Association
UR  - https://dx.doi.org/10.1093/jbcr/irab102
ER  -