TY  - BOOK
AU  - Barnett, Christopher F
AU  - Kenigsberg, Benjamin
AU  - Papolos, Alexander
TI  - Epidemiology of Acute Heart Failure in Critically Ill Patients with COVID-19: An Analysis from the Critical Care Cardiology Trials Network
PY  - 2022///
KW  - *Cardiology
KW  - *COVID-19
KW  - *Heart Failure
KW  - Biomarkers
KW  - COVID-19/ep [Epidemiology]
KW  - Critical Care
KW  - Critical Illness/ep [Epidemiology]
KW  - Heart Failure/di [Diagnosis]
KW  - Heart Failure/ep [Epidemiology]
KW  - Heart Failure/th [Therapy]
KW  - Hospital Mortality
KW  - Humans
KW  - Intensive Care Units
KW  - Shock, Cardiogenic/di [Diagnosis]
KW  - Shock, Cardiogenic/ep [Epidemiology]
KW  - Shock, Cardiogenic/th [Therapy]
KW  - Troponin
KW  - MedStar Heart & Vascular Institute
KW  - Journal Article
N1  - Available online from MWHC library: 1995 - present
N2  - BACKGROUND: Acute heart failure (HF) is an important complication of coronavirus disease 2019 (COVID-19) and has been hypothesized to relate to inflammatory activation; CONCLUSIONS: Among critically ill COVID-19 patients, acute HF is distinguished more by biomarkers of myocardial injury and hemodynamic stress than by biomarkers of inflammation. Copyright (c) 2022 The Authors. Published by Elsevier Inc. All rights reserved; METHODS: We evaluated consecutive intensive care unit (ICU) admissions for COVID-19 across 6 centers in the Critical Care Cardiology Trials Network, identifying patients with vs. without acute HF. Acute HF was sub-classified as "de novo" vs. "acute-on-chronic" based on the absence or presence of prior HF. Clinical features, biomarker profiles, and outcomes were compared; RESULTS: Among 901 COVID-19 ICU admissions, 80 (8.9%) had acute HF, including 18 (2.0%) with classic cardiogenic shock (CS) and 37 (4.1%) with vasodilatory CS. The majority (n=45) were de novo HF presentations. Compared to patients without acute HF, those with acute HF had higher cardiac troponin (cTn) and natriuretic peptides, and similar inflammatory biomarkers; patients with de novo HF had the highest cTn. Notably, among critically ill patients with COVID-19, illness severity (median SOFA, 8 [IQR, 5-10] vs. 6 [4-9]; p=0.025) and mortality (43.8% vs. 32.4%; p=0.040) were modestly higher in patients with vs. without acute HF
UR  - https://dx.doi.org/10.1016/j.cardfail.2021.12.020
ER  -