Name of journal: Journal of cardiac failureAbstract: BACKGROUND: Continuous infusion of ambulatory inotropic therapy (AIT) is increasingly used in patients with end stage heart failure (HF). There is a paucity of data on the concomitant use of beta blockers (BB) in these patients.CONCLUSION: In patients with end-stage heart failure on AIT, the use of BB with inotropes was associated with lower HF hospitalizations and ventricular arrhythmias. Copyright © 2022. Published by Elsevier Inc.METHODS: We retrospectively reviewed all patients discharged from our institution on AIT. The cohort was stratified into two groups based on BB use. The 2 groups were compared for differences in HF hospitalizations, ventricular arrhythmias, and ICD therapies (shock or anti-tachycardia pacing).RESULTS: Between 2010 and 2017, 349 patients were discharged on AIT (95% on Milrinone), 74% were males with a mean age of 61 +/-14 years. BB were used in 195 (56%) patients, whereas 154 (44%) did not receive these medications. Patients in the BB-group had longer duration of AIT support compared to those in the non-BB group (141 [1-2114] vs. 68 [1-690] days). After adjusting for differences in baseline characteristics and indication for AIT, patients in the BB-group had significantly lower rates of HF-hospitalizations (hazard ratio (HR) 0.61 [0.43-0.86], p= 0.005), ventricular arrhythmias (HR 0.34 [0.15-0.74], p=0.007)and ICD therapies (HR 0.24 [0.07-0.79], p=0.02).All authors: Ahmed S, Chou J, Ghazzal A, Hamad A, Hofmeyervb M, Kadakkal A, Lam PH, Molina EJ, Najjar SS, Radwan S, Rao SD, Rodrigo ME, Sheikh FH, Weintraub WS, Zaghlol L, Zaghlol RFiscal year: FY2022 Digital Object Identifier:

https://dx.doi.org/10.1016/j.cardfail.2022.03.352

Date added to catalog: 2022-05-11

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Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	35447337	Available		35447337

BACKGROUND: Continuous infusion of ambulatory inotropic therapy (AIT) is increasingly used in patients with end stage heart failure (HF). There is a paucity of data on the concomitant use of beta blockers (BB) in these patients.

CONCLUSION: In patients with end-stage heart failure on AIT, the use of BB with inotropes was associated with lower HF hospitalizations and ventricular arrhythmias. Copyright © 2022. Published by Elsevier Inc.

METHODS: We retrospectively reviewed all patients discharged from our institution on AIT. The cohort was stratified into two groups based on BB use. The 2 groups were compared for differences in HF hospitalizations, ventricular arrhythmias, and ICD therapies (shock or anti-tachycardia pacing).

RESULTS: Between 2010 and 2017, 349 patients were discharged on AIT (95% on Milrinone), 74% were males with a mean age of 61 +/-14 years. BB were used in 195 (56%) patients, whereas 154 (44%) did not receive these medications. Patients in the BB-group had longer duration of AIT support compared to those in the non-BB group (141 [1-2114] vs. 68 [1-690] days). After adjusting for differences in baseline characteristics and indication for AIT, patients in the BB-group had significantly lower rates of HF-hospitalizations (hazard ratio (HR) 0.61 [0.43-0.86], p= 0.005), ventricular arrhythmias (HR 0.34 [0.15-0.74], p=0.007)and ICD therapies (HR 0.24 [0.07-0.79], p=0.02).

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