Breath Hydrogen as a Biomarker for Glucose Malabsorption after Roux-en-Y Gastric Bypass Surgery.
Citation: Disease Markers. 2015:102760, 2015.PMID: 26538792Institution: MedStar Washington Hospital Center | MedStar Washington Hospital Center | MedStar Washington Hospital CenterDepartment: Medicine | Medicine/Gastroenterology | SurgeryForm of publication: Journal ArticleMedline article type(s): Evaluation Studies | Journal ArticleSubject headings: *Breath Tests/mt [Methods] | *Carbohydrate Metabolism, Inborn Errors/di [Diagnosis] | *Gastric Bypass/ae [Adverse Effects] | *Hydrogen/an [Analysis] | *Malabsorption Syndromes/di [Diagnosis] | Adult | Biomarkers/an [Analysis] | Carbohydrate Metabolism, Inborn Errors/et [Etiology] | Female | Humans | Intestines/mi [Microbiology] | Malabsorption Syndromes/et [Etiology] | Male | Methane/an [Analysis] | Middle AgedYear: 2015ISSN:- 0278-0240
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
---|---|---|---|---|---|---|
Journal Article | MedStar Authors Catalog | Article | 26538792 | Available | 26538792 |
CONCLUSION: These data support the presence of intestinal glucose malabsorption associated with upper gut bacterial overgrowth in individuals with abdominal symptoms after gastric bypass surgery. Breath hydrogen testing after oral glucose should be considered to evaluate potential malabsorption in symptomatic, postoperative individuals.
METHODS: This is a retrospective study of individuals (n = 63; 60 females; 3 males; mean age 49 years) who had gastric bypass surgery and then glucose breath testing to evaluate abdominal symptoms.
OBJECTIVE: Abdominal symptoms are common after bariatric surgery, and these individuals commonly have upper gut bacterial overgrowth, a known cause of malabsorption. Breath hydrogen determination after oral glucose is a safe and inexpensive test for malabsorption. This study is designed to investigate breath hydrogen levels after oral glucose in symptomatic individuals who had undergone Roux-en-Y gastric bypass surgery.
RESULTS: Among 63 postoperative individuals, 51 (81%) had a late rise (>45 minutes) in breath hydrogen or methane, supporting glucose malabsorption; 46 (90%) of these 51 subjects also had an early rise (<30 minutes) in breath hydrogen or methane supporting upper gut bacterial overgrowth. Glucose malabsorption was more frequent in subjects with upper gut bacterial overgrowth compared to subjects with no evidence for bacterial overgrowth (P < 0.001).
English