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Hospital resource use of patients receiving isavuconazole vs voriconazole for invasive mold infections in the phase III SECURE trial.

Contributor(s):

Shorr, Andrew F

Publication details: 2016; ISSN:

1369-6998

Subject(s):

Online resources:

https://dx.doi.org/10.3111/13696998.2016.1164175

Summary: CONCLUSIONS: Isavuconazole may reduce hospital LOS in certain subgroups of patients with IMD, especially those with moderate-to-severe renal impairment.Summary: LIMITATIONS: As the patient subgroups analyzed were small, sub-group findings should be interpreted with caution in light of the lack of statistical significance for each sub-group-by-treatment interaction.Summary: METHODS: The analysis population comprised adults with proven/probable/possible IMD enrolled in SECURE. The primary endpoint was hospital length of stay (LOS) in the overall trial population. Patients were also stratified by estimated glomerular filtration rate-modification of diet in renal disease category (< 60mL/min/1.73 m(2) [moderate-to-severe impairment] and >60mL/min/1.73 m(2) [mild or no impairment]), body mass index (BMI; <25, >25-<30, and >30kg/m(2)), and age (<45, >45-<65, and >65 years).Summary: RESULTS: Data from 516 patients (258 per arm) were evaluated. Overall, median LOS was not statistically significantly different between the isavuconazole (15.0 days) and voriconazole (16.0 days; p=0.607) arms. Median LOS was statistically significantly shorter in patients with moderate-to-severe renal impairment treated with isavuconazole (9.0 days) vs voriconazole (19.0 days; hazard ratio [HR]: 3.44; 95% confidence interval [CI]=1.51-7.83). Median LOS was shorter, but not significantly, in patients with a BMI >30kg/m(2) (isavuconazole 13.5 days vs voriconazole 22 days; HR=1.57; 95% CI=0.70-3.52) or aged >65 years (isavuconazole 15.0 days vs voriconazole 20.0 days; HR=1.37; 95% CI=0.87-2.16).

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Title notes ( 5 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	26960060	Available		26960060

CONCLUSIONS: Isavuconazole may reduce hospital LOS in certain subgroups of patients with IMD, especially those with moderate-to-severe renal impairment.

LIMITATIONS: As the patient subgroups analyzed were small, sub-group findings should be interpreted with caution in light of the lack of statistical significance for each sub-group-by-treatment interaction.

METHODS: The analysis population comprised adults with proven/probable/possible IMD enrolled in SECURE. The primary endpoint was hospital length of stay (LOS) in the overall trial population. Patients were also stratified by estimated glomerular filtration rate-modification of diet in renal disease category (< 60mL/min/1.73 m(2) [moderate-to-severe impairment] and >60mL/min/1.73 m(2) [mild or no impairment]), body mass index (BMI; <25, >25-<30, and >30kg/m(2)), and age (<45, >45-<65, and >65 years).

RESULTS: Data from 516 patients (258 per arm) were evaluated. Overall, median LOS was not statistically significantly different between the isavuconazole (15.0 days) and voriconazole (16.0 days; p=0.607) arms. Median LOS was statistically significantly shorter in patients with moderate-to-severe renal impairment treated with isavuconazole (9.0 days) vs voriconazole (19.0 days; hazard ratio [HR]: 3.44; 95% confidence interval [CI]=1.51-7.83). Median LOS was shorter, but not significantly, in patients with a BMI >30kg/m(2) (isavuconazole 13.5 days vs voriconazole 22 days; HR=1.57; 95% CI=0.70-3.52) or aged >65 years (isavuconazole 15.0 days vs voriconazole 20.0 days; HR=1.37; 95% CI=0.87-2.16).

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