000			03624nam a22005177a 4500
008			160907s20142014 xxu||||| |||| 00| 0 eng d
022			_a1530-891X
040			_aOvid MEDLINE(R)
099			_a24518182
245			_a3,3'-Diiodothyronine concentrations in hospitalized or thyroidectomized patients: results from a pilot study.
251			_aEndocrine Practice. 20(8):797-807, 2014 Aug.
252			_aEndocr Pract. 20(8):797-807, 2014 Aug.
253			_aEndocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
260			_c2014
260			_fFY2015
266			_d2016-09-07
520			_aCONCLUSION: We observed associations between inpatient status and reduced 3,3'-T2 concentrations. This appears to be a global change associated with illness, rather than an association with specific medical conditions. We also observed higher 3,3'-T2 concentrations in athyreotic outpatients receiving thyroid-stimulating hormone (TSH) suppression therapy. This demonstrates that there is production of 3,3'-T2 from levothyroxine (LT4) in extrathyroidal tissues. Conversion of thyroxine (T4) to 3,3'-T2 via both triiodothyronine (T3) and reverse triiodothyronine (rT3) pathways may prevent excessive T3 concentrations in such patients.
520			_aMETHODS: A total of 100 patients who were recruited from a group of inpatients and outpatients with a diverse range of medical conditions, donated a single blood sample that was assayed for thyroid hormone derivatives using liquid-chromatography tandem mass spectrometry (LC-MS/MS). The associations between 3,3'-T2 concentrations and physiologic data and medical conditions were assessed.
520			_aOBJECTIVE: To determine if various medical conditions affect the serum concentrations of 3,3'-diiodothyronine (3,3'-T2).
520			_aRESULTS: Higher quartiles of 3,3'-T2 concentrations (quartile 1: 2.01-7.48, quartile 2: 7.74-12.4, quartile 3: 12.5-17, quartile 4: 17.9-45.8 pg/mL) were associated with decreasing occurrence of critical illness (58%, 11%, 0%, 8%), stroke (29%, 7.7%, 4%, 0%), critical care unit hospitalization (75%, 39%, 8.3 %, 12%), and inpatient status (83%, 42%, 8%, 12%) (all P<.001). The same quartiles were associated with increasing frequency of thyroidectomy (4%, 12%, 17%, 60%). In multivariate analyses, after adjustment for age and sex, inpatient status was associated with decreasing concentrations of 3,3'-T2 (46% decrease for inpatients with 95% confidence interval [CI] 32-57%, P<.0001). Thyroidectomy was associated with increasing concentrations of 3,3'-T2 (29% increase (CI 0.5-66%, P = .049).
546			_aEnglish
650			_a*Diiodothyronines/bl [Blood]
650			_a*Thyroidectomy
650			_aAdult
650			_aAged
650			_aFemale
650			_aHospitalization
650			_aHumans
650			_aMale
650			_aMiddle Aged
650			_aPilot Projects
650			_aTandem Mass Spectrometry
650			_aTriiodothyronine/bl [Blood]
651			_aMedStar Health Research Institute
651			_aMedStar Washington Hospital Center
656			_aMedicine/Endocrinology
657			_aJournal Article
657			_aResearch Support, N.I.H., Extramural
700			_aBurman, Kenneth D
700			_aJonklaas, Jacqueline
700			_aSathasivam, Anpalakan
700			_aWang, Hong
790			_aBurman KD, Finigan D, Jonklaas J, Sathasivam A, Soldin OP, Soldin SJ, Wang H
856			_uhttp://dx.doi.org/10.4158/EP13453.OR _zhttp://dx.doi.org/10.4158/EP13453.OR
942			_cART _dArticle
999			_c1929 _d1929