000			04110nam a22006617a 4500
008			170428s20172017 xxu||||| |||| 00| 0 eng d
022			_a2153-7658
040			_aOvid MEDLINE(R)
099			_a27383062
245			_aThe Association Between Arterial Oxygen Tension and Neurological Outcome After Cardiac Arrest.
251			_aTherapeutic Hypothermia & Temperature Management. 7(1):36-41, 2017 Mar
252			_aTher. hypothermia temp. manag.. 7(1):36-41, 2017 Mar
253			_aTherapeutic hypothermia and temperature management
260			_c2017
260			_fFY2017
266			_d2017-05-06
520			_aA number of observational studies have evaluated the association between arterial oxygen tensions and outcome after cardiac arrest with variable results. The objective of this study is to determine the association between arterial oxygen tension and neurological outcome after cardiac arrest. A retrospective cohort analysis was performed using the Penn Alliance for Therapeutic Hypothermia registry. Adult patients who experienced return of spontaneous circulation after in-hospital or out-of-hospital cardiac arrest (OHCA) and had a partial pressure of arterial oxygen (PaO<sub>2</sub>) recorded within 48 hours were included. Our primary exposure of interest was PaO<sub>2</sub>. Hyperoxemia was defined as PaO<sub>2</sub> > 300mmHg, hypoxemia as PaO<sub>2</sub> < 60mmHg, and optimal oxygenation as PaO<sub>2</sub> 60-300mmHg. The primary outcome was neurological function at hospital discharge among survivors, as described by the cerebral performance category (CPC) score, dichotomized into "favorable" (CPCs 1-2) and "unfavorable" (CPCs 3-5). Secondary outcomes included in-hospital mortality. A total of 544 patients from 13 institutions were included. Average age was 61 years, 56% were male, and 51% were white. A total of 64% experienced OHCA, 81% of arrests were witnessed, and pulseless electrical activity was the most common initial rhythm (40%). More than 72% of the patients had cardiac etiology for their arrests, and 55% underwent targeted temperature management. A total of 38% of patients survived to hospital discharge. There was no significant association between PaO<sub>2</sub> at any time interval and neurological outcome at hospital discharge. Hyperoxemia at 12 hours after cardiac arrest was associated with decreased odds of survival (OR 0.17 [0.03-0.89], p=0.032). There was no significant association between arterial oxygen tension measured within the first 48 hours after cardiac arrest and neurological outcome.
546			_aEnglish
650			_a*Heart Arrest/bl [Blood]
650			_a*Heart Arrest/pp [Physiopathology]
650			_a*Nervous System/pp [Physiopathology]
650			_a*Oxygen/bl [Blood]
650			_aAdult
650			_aAged
650			_aAged, 80 and over
650			_aBiomarkers/bl [Blood]
650			_aFemale
650			_aHeart Arrest/mo [Mortality]
650			_aHeart Arrest/th [Therapy]
650			_aHospital Mortality
650			_aHumans
650			_aHyperoxia/bl [Blood]
650			_aHyperoxia/mo [Mortality]
650			_aHyperoxia/pp [Physiopathology]
650			_aHypothermia, Induced
650			_aHypoxia/bl [Blood]
650			_aHypoxia/mo [Mortality]
650			_aHypoxia/pp [Physiopathology]
650			_aMale
650			_aMiddle Aged
650			_aPartial Pressure
650			_aRecovery of Function
650			_aRegistries
650			_aRespiration, Artificial
650			_aResuscitation/mt [Methods]
650			_aRetrospective Studies
650			_aRisk Factors
650			_aTime Factors
650			_aTreatment Outcome
650			_aUnited States
651			_aMedStar Washington Hospital Center
656			_aEmergency Medicine
657			_aJournal Article
700			_aGoyal, Munish
790			_aDodampahala K, Gaieski DF, Goyal M, Grossestreuer AV, Johnson NJ, Mikkelsen ME, Perman SM, Rosselot B
856			_uhttps://dx.doi.org/10.1089/ther.2016.0015 _zhttps://dx.doi.org/10.1089/ther.2016.0015
942			_cART _dArticle
999			_c2524 _d2524