000			04674nam a22009017a 4500
008			190521s20192019 xxu||||| |||| 00| 0 eng d
022			_a1878-0938
024			_a10.1016/j.carrev.2019.02.015 [doi]
024			_aS1553-8389(19)30148-4 [pii]
040			_aOvid MEDLINE(R)
099			_a31079816
245			_aTranscatheter Aortic Valve Replacement in Patients With Symptomatic Severe Aortic Stenosis and Prior External Chest Radiation.
251			_aCardiovascular Revascularization Medicine. 20(5):376-380, 2019 05.
252			_aCardiovasc Revasc Med. 20(5):376-380, 2019 05.
252			_zCardiovasc Revasc Med. 20(5):376-380, 2019 May.
253			_aCardiovascular revascularization medicine : including molecular interventions
260			_c2019
260			_fFY2019
265			_sppublish
266			_d2019-05-21
268			_aCardiovascular Revascularization Medicine. 20(5):376-380, 2019 May.
501			_aAvailable in print through MWHC library: 2002 - present
520			_aBACKGROUND/PURPOSE: Surgical aortic valve replacement (SAVR) in patients with symptomatic severe aortic stenosis (AS) and prior chest radiation is associated with poor outcomes in comparison with patients without prior radiation. Our objective was to compare clinical outcomes of patients with and without prior chest radiation undergoing transcatheter aortic valve replacement (TAVR) for symptomatic severe AS.
520			_aCONCLUSIONS: Thus, TAVR appears to be a safe treatment option in the short and medium term for patients with symptomatic severe AS and prior chest radiation.
520			_aCopyright (c) 2019. Published by Elsevier Inc.
520			_aMETHODS/MATERIALS: Between January 2003 and January 2017, 1150 patients underwent TAVR at our institution. Of these, 44 had prior chest radiation. Baseline demographic and clinical characteristics, procedural details, and clinical outcomes were prospectively collected.
520			_aRESULTS: Patients with prior chest radiation were younger, 76+/-13years, compared with those without prior chest radiation, 82+/-8years (p=0.002). Median Society of Thoracic Surgeons score for chest radiation patients was 7+/-4, compared to 8+/-5 in those without prior radiation. Despite higher prevalence of complete heart block, there was no significant difference between the 2 groups with regard to the need for permanent pacemaker implantation. There was a trend toward longer length of intensive care unit stay in chest radiation patients, but there was no significant difference in 30-day or 1-year mortality.
546			_aEnglish
650			_a*Aortic Valve Stenosis/su [Surgery]
650			_a*Aortic Valve/su [Surgery]
650			_a*Cancer Survivors
650			_a*Thorax/re [Radiation Effects]
650			_a*Transcatheter Aortic Valve Replacement
650			_aAged
650			_aAged, 80 and over
650			_aAortic Valve Stenosis/dg [Diagnostic Imaging]
650			_aAortic Valve Stenosis/mo [Mortality]
650			_aAortic Valve Stenosis/pp [Physiopathology]
650			_aAortic Valve/dg [Diagnostic Imaging]
650			_aAortic Valve/pp [Physiopathology]
650			_aDistrict of Columbia/ep [Epidemiology]
650			_aFemale
650			_aHeart Block/ep [Epidemiology]
650			_aHeart Block/th [Therapy]
650			_aHemodynamics
650			_aHumans
650			_aLength of Stay
650			_aMale
650			_aMiddle Aged
650			_aPrevalence
650			_aProspective Studies
650			_aRadiotherapy
650			_aRisk Factors
650			_aSeverity of Illness Index
650			_aTime Factors
650			_aTranscatheter Aortic Valve Replacement/ae [Adverse Effects]
650			_aTranscatheter Aortic Valve Replacement/mo [Mortality]
650			_aTreatment Outcome
651			_aMedStar Heart & Vascular Institute
657			_aJournal Article
700			_aAttaran, Saina
700			_aBen-Dor, Itsik
700			_aBuchanan, Kyle
700			_aGajanana, Deepakraj
700			_aIantorno, Micaela
700			_aKolm, Paul
700			_aOkubagzi, Petros
700			_aRogers, Toby
700			_aSatler, Lowell F
700			_aThourani, Vinod H
700			_aTorguson, Rebecca
700			_aWaksman, Ron
700			_aWeintraub, William S
700			_aZhang, Cheng
790			_aAttaran S, Ben-Dor I, Buchanan KD, Gajanana D, Iantorno M, Kolm P, Okubagzi PG, Rogers T, Satler LF, Thourani VH, Torguson R, Waksman R, Weintraub WS, Zhang C
856			_uhttps://dx.doi.org/10.1016/j.carrev.2019.02.015 _zhttps://dx.doi.org/10.1016/j.carrev.2019.02.015
942			_cART _dArticle
999			_c4239 _d4239